Role of Apoptosis in HIV Pathogenesis
The apoptotic pathway is an important cell death pathway that contributes to the maintenance of homeostasis in living systems. However, variations in apoptosis have been linked to many diseases such as cancers and chronic infections. The HIV infection has contributed to increase mortality and morbid...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2022/8148119 |
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| _version_ | 1832565745063559168 |
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| author | Cyril Jabea Ekabe Njinju Asaba Clinton Eugene Kusi Agyei Jules Kehbila |
| author_facet | Cyril Jabea Ekabe Njinju Asaba Clinton Eugene Kusi Agyei Jules Kehbila |
| author_sort | Cyril Jabea Ekabe |
| collection | DOAJ |
| description | The apoptotic pathway is an important cell death pathway that contributes to the maintenance of homeostasis in living systems. However, variations in apoptosis have been linked to many diseases such as cancers and chronic infections. The HIV infection has contributed to increase mortality and morbidity worldwide, predominantly through the induction of gradual depletion of CD4+ T cells. The induction and mediation of both the intrinsic and extrinsic apoptotic pathways are crucial in HIV pathogenesis and intracellular survival. Consequently, a deep molecular understanding of how apoptosis is induced and modulated in HIV-mediated CD4+ T cell depletion is paramount, as this can lead to new portals of therapeutic intervention and control. |
| format | Article |
| id | doaj-art-cade781b4740495d91caddcf0650f50f |
| institution | Kabale University |
| issn | 1687-8647 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-cade781b4740495d91caddcf0650f50f2025-02-03T01:06:51ZengWileyAdvances in Virology1687-86472022-01-01202210.1155/2022/8148119Role of Apoptosis in HIV PathogenesisCyril Jabea Ekabe0Njinju Asaba Clinton1Eugene Kusi Agyei2Jules Kehbila3Grace Community Health and Development AssociationGrace Community Health and Development AssociationFaculty of Pharmacy and Pharmaceutical SciencesGrace Community Health and Development AssociationThe apoptotic pathway is an important cell death pathway that contributes to the maintenance of homeostasis in living systems. However, variations in apoptosis have been linked to many diseases such as cancers and chronic infections. The HIV infection has contributed to increase mortality and morbidity worldwide, predominantly through the induction of gradual depletion of CD4+ T cells. The induction and mediation of both the intrinsic and extrinsic apoptotic pathways are crucial in HIV pathogenesis and intracellular survival. Consequently, a deep molecular understanding of how apoptosis is induced and modulated in HIV-mediated CD4+ T cell depletion is paramount, as this can lead to new portals of therapeutic intervention and control.http://dx.doi.org/10.1155/2022/8148119 |
| spellingShingle | Cyril Jabea Ekabe Njinju Asaba Clinton Eugene Kusi Agyei Jules Kehbila Role of Apoptosis in HIV Pathogenesis Advances in Virology |
| title | Role of Apoptosis in HIV Pathogenesis |
| title_full | Role of Apoptosis in HIV Pathogenesis |
| title_fullStr | Role of Apoptosis in HIV Pathogenesis |
| title_full_unstemmed | Role of Apoptosis in HIV Pathogenesis |
| title_short | Role of Apoptosis in HIV Pathogenesis |
| title_sort | role of apoptosis in hiv pathogenesis |
| url | http://dx.doi.org/10.1155/2022/8148119 |
| work_keys_str_mv | AT cyriljabeaekabe roleofapoptosisinhivpathogenesis AT njinjuasabaclinton roleofapoptosisinhivpathogenesis AT eugenekusiagyei roleofapoptosisinhivpathogenesis AT juleskehbila roleofapoptosisinhivpathogenesis |