Antibiotic-persistent bacterial cells exhibiting low-level ROS are eradicated by ROS-independent membrane disruption

Antibiotic-persistent bacterial cells exhibiting low-level ROS are eradicated by ROS-independent membrane disruption

ABSTRACT Bacterial persistence increases therapy duration, disease relapse, and antibiotic resistance. Mechanisms underlying persistence and feasible ways to rapidly eliminate persister cells are largely unknown. The present work examined genetic and environmental perturbations to identify anti-deat...

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Bibliographic Details
Main Authors: Yanghui Ye, Yuanqing Tian, Mingxin Duan, Weiwei Zhu, Jingyun Wu, Yilin Chen, Feng Xu, Xilin Zhao, Karl Drlica, Yuzhi Hong
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
antibiotic
cell death
persistence
tolerance
reactive oxygen species
membrane damage
Online Access:https://journals.asm.org/doi/10.1128/mbio.01199-25
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