Cerebral Sinus Venous Thrombosis due to Asparaginase Therapy
We report a 9-year-old boy with acute lymphoblastic leukemia (ALL) in high-risk group who suffered from left sided focal seizures and ipsilateral hemiparesis during his induction with Asparaginase chemotherapy. Superior sagittal sinus thrombosis and right frontal hemorrhage were demonstrated on brai...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/841057 |
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| author | Youssef Alsaid Shamshad Gulab Mohammed Bayoumi Saleh Baeesa |
| author_facet | Youssef Alsaid Shamshad Gulab Mohammed Bayoumi Saleh Baeesa |
| author_sort | Youssef Alsaid |
| collection | DOAJ |
| description | We report a 9-year-old boy with acute lymphoblastic leukemia (ALL) in high-risk group who suffered from left sided focal seizures and ipsilateral hemiparesis during his induction with Asparaginase chemotherapy. Superior sagittal sinus thrombosis and right frontal hemorrhage were demonstrated on brain magnetic resonance imaging (MRI) scans . Anticoagulation was initiated with unfractionated heparin and switched to low molecular weight heparin after 3 weeks and continued for 6 months. At one-year followup, he had complete response to chemotherapy for ALL, with residual mild left hemiparesis, and his MRI scans revealed recanalized venous sinuses. The case highlights the importance of considering cerebral venous thrombosis as a complication of Asparaginase therapy. |
| format | Article |
| id | doaj-art-cad5b5e9b29e424ca4f0429592d46ba8 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-cad5b5e9b29e424ca4f0429592d46ba82025-02-03T01:31:57ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/841057841057Cerebral Sinus Venous Thrombosis due to Asparaginase TherapyYoussef Alsaid0Shamshad Gulab1Mohammed Bayoumi2Saleh Baeesa3Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, P.O. Box 40047, MBC J-76, Jeddah 21499, Saudi ArabiaDepartment of Neurosciences, King Faisal Specialist Hospital and Research Centre, P.O. Box 40047, MBC J-76, Jeddah 21499, Saudi ArabiaDepartment of Hematological Oncology, King Faisal Specialist Hospital and Research Centre, P.O. Box 40047, MBC J-76, Jeddah 21499, Saudi ArabiaDivision of Neurosurgery, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaWe report a 9-year-old boy with acute lymphoblastic leukemia (ALL) in high-risk group who suffered from left sided focal seizures and ipsilateral hemiparesis during his induction with Asparaginase chemotherapy. Superior sagittal sinus thrombosis and right frontal hemorrhage were demonstrated on brain magnetic resonance imaging (MRI) scans . Anticoagulation was initiated with unfractionated heparin and switched to low molecular weight heparin after 3 weeks and continued for 6 months. At one-year followup, he had complete response to chemotherapy for ALL, with residual mild left hemiparesis, and his MRI scans revealed recanalized venous sinuses. The case highlights the importance of considering cerebral venous thrombosis as a complication of Asparaginase therapy.http://dx.doi.org/10.1155/2013/841057 |
| spellingShingle | Youssef Alsaid Shamshad Gulab Mohammed Bayoumi Saleh Baeesa Cerebral Sinus Venous Thrombosis due to Asparaginase Therapy Case Reports in Hematology |
| title | Cerebral Sinus Venous Thrombosis due to Asparaginase Therapy |
| title_full | Cerebral Sinus Venous Thrombosis due to Asparaginase Therapy |
| title_fullStr | Cerebral Sinus Venous Thrombosis due to Asparaginase Therapy |
| title_full_unstemmed | Cerebral Sinus Venous Thrombosis due to Asparaginase Therapy |
| title_short | Cerebral Sinus Venous Thrombosis due to Asparaginase Therapy |
| title_sort | cerebral sinus venous thrombosis due to asparaginase therapy |
| url | http://dx.doi.org/10.1155/2013/841057 |
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