Pharmacogenetics of Chronic Pain and Its Treatment
This paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. Several candidate genes have been identified in the l...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/864319 |
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| _version_ | 1832564223278841856 |
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| author | Svatopluk Světlík Karolína Hronová Hana Bakhouche Olga Matoušková Ondřej Slanař |
| author_facet | Svatopluk Světlík Karolína Hronová Hana Bakhouche Olga Matoušková Ondřej Slanař |
| author_sort | Svatopluk Světlík |
| collection | DOAJ |
| description | This paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. Several candidate genes have been identified in the literature, while there is usually only limited clinical evidence substantiating for the penetration of the testing for these candidate biomarkers into the clinical practice. Further, the pain-perception regulation and modulation are still not fully understood, and thus more complex knowledge of genetic and epigenetic background for analgesia will be needed prior to the clinical use of the candidate genetic biomarkers. |
| format | Article |
| id | doaj-art-cad2fa2a418545cc9d580db408ea1086 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cad2fa2a418545cc9d580db408ea10862025-02-03T01:11:32ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/864319864319Pharmacogenetics of Chronic Pain and Its TreatmentSvatopluk Světlík0Karolína Hronová1Hana Bakhouche2Olga Matoušková3Ondřej Slanař4Institute of Pharmacology, First Faculty of Medicine, Charles University Prague, Albertov 4, 12800 Prague, Czech RepublicInstitute of Pharmacology, First Faculty of Medicine, Charles University Prague, Albertov 4, 12800 Prague, Czech RepublicInstitute of Pharmacology, First Faculty of Medicine, Charles University Prague, Albertov 4, 12800 Prague, Czech RepublicInstitute of Pharmacology, First Faculty of Medicine, Charles University Prague, Albertov 4, 12800 Prague, Czech RepublicInstitute of Pharmacology, First Faculty of Medicine, Charles University Prague, Albertov 4, 12800 Prague, Czech RepublicThis paper reviews the impact of genetic variability of drug metabolizing enzymes, transporters, receptors, and pathways involved in chronic pain perception on the efficacy and safety of analgesics and other drugs used for chronic pain treatment. Several candidate genes have been identified in the literature, while there is usually only limited clinical evidence substantiating for the penetration of the testing for these candidate biomarkers into the clinical practice. Further, the pain-perception regulation and modulation are still not fully understood, and thus more complex knowledge of genetic and epigenetic background for analgesia will be needed prior to the clinical use of the candidate genetic biomarkers.http://dx.doi.org/10.1155/2013/864319 |
| spellingShingle | Svatopluk Světlík Karolína Hronová Hana Bakhouche Olga Matoušková Ondřej Slanař Pharmacogenetics of Chronic Pain and Its Treatment Mediators of Inflammation |
| title | Pharmacogenetics of Chronic Pain and Its Treatment |
| title_full | Pharmacogenetics of Chronic Pain and Its Treatment |
| title_fullStr | Pharmacogenetics of Chronic Pain and Its Treatment |
| title_full_unstemmed | Pharmacogenetics of Chronic Pain and Its Treatment |
| title_short | Pharmacogenetics of Chronic Pain and Its Treatment |
| title_sort | pharmacogenetics of chronic pain and its treatment |
| url | http://dx.doi.org/10.1155/2013/864319 |
| work_keys_str_mv | AT svatopluksvetlik pharmacogeneticsofchronicpainanditstreatment AT karolinahronova pharmacogeneticsofchronicpainanditstreatment AT hanabakhouche pharmacogeneticsofchronicpainanditstreatment AT olgamatouskova pharmacogeneticsofchronicpainanditstreatment AT ondrejslanar pharmacogeneticsofchronicpainanditstreatment |