T Cell Activation and Regulation of HIV-1: Same Effectors with Distinct Outcomes
The molecular mechanisms that regulate the function of the immune system and human immunodeficiency virus type-1 (HIV-1) gene expression are diverse and complicated. However, replication of HIV-1 is controlled by many of the same regulatory signals that play a crucial role in the transcriptional reg...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1999/717641 |
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| _version_ | 1832555358844878848 |
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| author | Jean-François Fortin Benoit Barbeau Gilles A Robichaud Michel J Tremblay |
| author_facet | Jean-François Fortin Benoit Barbeau Gilles A Robichaud Michel J Tremblay |
| author_sort | Jean-François Fortin |
| collection | DOAJ |
| description | The molecular mechanisms that regulate the function of the immune system and human immunodeficiency virus type-1
(HIV-1) gene expression are diverse and complicated. However, replication of HIV-1 is controlled by many of the same
regulatory signals that play a crucial role in the transcriptional regulation of the immune system. For example, the viral
promoter, as is the case for the immune system, is subject to complex regulation by combinations of cellular transcription
factors that may quantitatively and/or qualitatively differ depending on cell types (eg, macrophages versus T lymphocytes)
and cell states (eg, undifferentiated versus differentiated or quiescent versus activated). The present review
discusses the regulation of HIV-1 gene expression by nuclear factor-kappa Band nuclear factor of activated T cells, and
proposes that selective interference of these two cellular transcription factors may be a route to abrogate virus replication
without disrupting normal cellular functions. A better understanding of the regulation of HIV-1 gene expression is
of utmost importance for the design of molecular approaches that will effectively abrogate virus replication and, ultimately,
disease progression. |
| format | Article |
| id | doaj-art-cacadbb5d67a4a7d9af5c608de67f075 |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-cacadbb5d67a4a7d9af5c608de67f0752025-02-03T05:48:26ZengWileyCanadian Journal of Infectious Diseases1180-23321999-01-0110Suppl C25C32C10.1155/1999/717641T Cell Activation and Regulation of HIV-1: Same Effectors with Distinct OutcomesJean-François Fortin0Benoit Barbeau1Gilles A Robichaud2Michel J Tremblay3Centre de Recherche en Infectiologie, Université Laval, Ste-Foy, Québec, CanadaCentre de Recherche en Infectiologie, Université Laval, Ste-Foy, Québec, CanadaCentre de Recherche en Infectiologie, Université Laval, Ste-Foy, Québec, CanadaCentre de Recherche en Infectiologie, Université Laval, Ste-Foy, Québec, CanadaThe molecular mechanisms that regulate the function of the immune system and human immunodeficiency virus type-1 (HIV-1) gene expression are diverse and complicated. However, replication of HIV-1 is controlled by many of the same regulatory signals that play a crucial role in the transcriptional regulation of the immune system. For example, the viral promoter, as is the case for the immune system, is subject to complex regulation by combinations of cellular transcription factors that may quantitatively and/or qualitatively differ depending on cell types (eg, macrophages versus T lymphocytes) and cell states (eg, undifferentiated versus differentiated or quiescent versus activated). The present review discusses the regulation of HIV-1 gene expression by nuclear factor-kappa Band nuclear factor of activated T cells, and proposes that selective interference of these two cellular transcription factors may be a route to abrogate virus replication without disrupting normal cellular functions. A better understanding of the regulation of HIV-1 gene expression is of utmost importance for the design of molecular approaches that will effectively abrogate virus replication and, ultimately, disease progression.http://dx.doi.org/10.1155/1999/717641 |
| spellingShingle | Jean-François Fortin Benoit Barbeau Gilles A Robichaud Michel J Tremblay T Cell Activation and Regulation of HIV-1: Same Effectors with Distinct Outcomes Canadian Journal of Infectious Diseases |
| title | T Cell Activation and Regulation of HIV-1: Same Effectors with Distinct Outcomes |
| title_full | T Cell Activation and Regulation of HIV-1: Same Effectors with Distinct Outcomes |
| title_fullStr | T Cell Activation and Regulation of HIV-1: Same Effectors with Distinct Outcomes |
| title_full_unstemmed | T Cell Activation and Regulation of HIV-1: Same Effectors with Distinct Outcomes |
| title_short | T Cell Activation and Regulation of HIV-1: Same Effectors with Distinct Outcomes |
| title_sort | t cell activation and regulation of hiv 1 same effectors with distinct outcomes |
| url | http://dx.doi.org/10.1155/1999/717641 |
| work_keys_str_mv | AT jeanfrancoisfortin tcellactivationandregulationofhiv1sameeffectorswithdistinctoutcomes AT benoitbarbeau tcellactivationandregulationofhiv1sameeffectorswithdistinctoutcomes AT gillesarobichaud tcellactivationandregulationofhiv1sameeffectorswithdistinctoutcomes AT micheljtremblay tcellactivationandregulationofhiv1sameeffectorswithdistinctoutcomes |