Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity
2-Acetyl benzofuran (1) was synthesized by refluxing salicylaldehyde and dry chloroacetone in presence of potassium carbonate. The product formed was reacted with 2-aminobenzothiazole with catalyst p-toluene sulphonic acid to form N-[(1Z)-1-(benzofuran-2-yl)ethylidene]1,3-benzothiazol-2-amine (2). I...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/817480 |
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| author | D. R. Harish Kumar M. D. Karvekar |
| author_facet | D. R. Harish Kumar M. D. Karvekar |
| author_sort | D. R. Harish Kumar |
| collection | DOAJ |
| description | 2-Acetyl benzofuran (1) was synthesized by refluxing salicylaldehyde and dry chloroacetone in presence of potassium carbonate. The product formed was reacted with 2-aminobenzothiazole with catalyst p-toluene sulphonic acid to form N-[(1Z)-1-(benzofuran-2-yl)ethylidene]1,3-benzothiazol-2-amine (2). In cold condition, Staudinger reaction was carried out for compound (2) with various acid chlorides in presence of triethylamine to synthesize 4-[1-benzofuran-2-yl]-1-[1, 3-benzothiazol-2-yl]-4-methylazetidin-2-one (3a-3j). All the synthesized compounds were characterized on the basis of analytical data. The compounds were screened for their antimicrobial activities. Compound 3b,3cand 3d exhibited moderate activity. |
| format | Article |
| id | doaj-art-cac28b1967064f14aa7b50707d4c8299 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-cac28b1967064f14aa7b50707d4c82992025-02-03T01:01:49ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017263664010.1155/2010/817480Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial ActivityD. R. Harish Kumar0M. D. Karvekar1Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bangalore-560035, IndiaDepartment of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bangalore-560035, India2-Acetyl benzofuran (1) was synthesized by refluxing salicylaldehyde and dry chloroacetone in presence of potassium carbonate. The product formed was reacted with 2-aminobenzothiazole with catalyst p-toluene sulphonic acid to form N-[(1Z)-1-(benzofuran-2-yl)ethylidene]1,3-benzothiazol-2-amine (2). In cold condition, Staudinger reaction was carried out for compound (2) with various acid chlorides in presence of triethylamine to synthesize 4-[1-benzofuran-2-yl]-1-[1, 3-benzothiazol-2-yl]-4-methylazetidin-2-one (3a-3j). All the synthesized compounds were characterized on the basis of analytical data. The compounds were screened for their antimicrobial activities. Compound 3b,3cand 3d exhibited moderate activity.http://dx.doi.org/10.1155/2010/817480 |
| spellingShingle | D. R. Harish Kumar M. D. Karvekar Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity E-Journal of Chemistry |
| title | Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity |
| title_full | Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity |
| title_fullStr | Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity |
| title_full_unstemmed | Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity |
| title_short | Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity |
| title_sort | synthesis of benzofuran derivatives and their evaluation of antimicrobial activity |
| url | http://dx.doi.org/10.1155/2010/817480 |
| work_keys_str_mv | AT drharishkumar synthesisofbenzofuranderivativesandtheirevaluationofantimicrobialactivity AT mdkarvekar synthesisofbenzofuranderivativesandtheirevaluationofantimicrobialactivity |