Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity
2-Acetyl benzofuran (1) was synthesized by refluxing salicylaldehyde and dry chloroacetone in presence of potassium carbonate. The product formed was reacted with 2-aminobenzothiazole with catalyst p-toluene sulphonic acid to form N-[(1Z)-1-(benzofuran-2-yl)ethylidene]1,3-benzothiazol-2-amine (2). I...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/817480 |
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| Summary: | 2-Acetyl benzofuran (1) was synthesized by refluxing salicylaldehyde and dry chloroacetone in presence of potassium carbonate. The product formed was reacted with 2-aminobenzothiazole with catalyst p-toluene sulphonic acid to form N-[(1Z)-1-(benzofuran-2-yl)ethylidene]1,3-benzothiazol-2-amine (2). In cold condition, Staudinger reaction was carried out for compound (2) with various acid chlorides in presence of triethylamine to synthesize 4-[1-benzofuran-2-yl]-1-[1, 3-benzothiazol-2-yl]-4-methylazetidin-2-one (3a-3j). All the synthesized compounds were characterized on the basis of analytical data. The compounds were screened for their antimicrobial activities. Compound 3b,3cand 3d exhibited moderate activity. |
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| ISSN: | 0973-4945 2090-9810 |