Epidemiology and Pathogenesis of Nasal NK/T-Cell Lymphoma: A Mini-Review
Nasal NK/T-cell lymphoma (NKTCL) frequently presents with necrotic, granulomatous lesions in the upper respiratory tract, and usually shows a highly aggressive clinical course. Thus, it was initially included in the clinical condition of lethal midline granuloma. Recently, the disease has been recog...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2011.41 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556219076706304 |
|---|---|
| author | Katsuyuki Aozasa Mona A. A. Zaki |
| author_facet | Katsuyuki Aozasa Mona A. A. Zaki |
| author_sort | Katsuyuki Aozasa |
| collection | DOAJ |
| description | Nasal NK/T-cell lymphoma (NKTCL) frequently presents with necrotic, granulomatous lesions in the upper respiratory tract, and usually shows a highly aggressive clinical course. Thus, it was initially included in the clinical condition of lethal midline granuloma. Recently, the disease has been recognized as a neoplastic proliferation of NK/T cells. The disease is much more frequent in Asian and Latin American countries than in Western countries, and is universally associated with Epstein-Barr virus (EBV) infection. Analyses of gene mutations, especially p53 and c-kit, revealed the different frequencies by district. Abnormalities of other genes have also been reported. Case-control studies showed that the exposure to pesticides and chemical solvents could be causative of NKTCL. Further studies including HLA antigen typing of patients is necessary to further clarify the disease mechanism. |
| format | Article |
| id | doaj-art-cac279e76a994697afeb62b3aae3c8e0 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-cac279e76a994697afeb62b3aae3c8e02025-02-03T05:46:01ZengWileyThe Scientific World Journal1537-744X2011-01-011142242810.1100/tsw.2011.41Epidemiology and Pathogenesis of Nasal NK/T-Cell Lymphoma: A Mini-ReviewKatsuyuki Aozasa0Mona A. A. Zaki1Department of Pathology, Osaka University, Graduate School of Medicine, Osaka, JapanDepartment of Pathology, Osaka University, Graduate School of Medicine, Osaka, JapanNasal NK/T-cell lymphoma (NKTCL) frequently presents with necrotic, granulomatous lesions in the upper respiratory tract, and usually shows a highly aggressive clinical course. Thus, it was initially included in the clinical condition of lethal midline granuloma. Recently, the disease has been recognized as a neoplastic proliferation of NK/T cells. The disease is much more frequent in Asian and Latin American countries than in Western countries, and is universally associated with Epstein-Barr virus (EBV) infection. Analyses of gene mutations, especially p53 and c-kit, revealed the different frequencies by district. Abnormalities of other genes have also been reported. Case-control studies showed that the exposure to pesticides and chemical solvents could be causative of NKTCL. Further studies including HLA antigen typing of patients is necessary to further clarify the disease mechanism.http://dx.doi.org/10.1100/tsw.2011.41 |
| spellingShingle | Katsuyuki Aozasa Mona A. A. Zaki Epidemiology and Pathogenesis of Nasal NK/T-Cell Lymphoma: A Mini-Review The Scientific World Journal |
| title | Epidemiology and Pathogenesis of Nasal NK/T-Cell Lymphoma: A Mini-Review |
| title_full | Epidemiology and Pathogenesis of Nasal NK/T-Cell Lymphoma: A Mini-Review |
| title_fullStr | Epidemiology and Pathogenesis of Nasal NK/T-Cell Lymphoma: A Mini-Review |
| title_full_unstemmed | Epidemiology and Pathogenesis of Nasal NK/T-Cell Lymphoma: A Mini-Review |
| title_short | Epidemiology and Pathogenesis of Nasal NK/T-Cell Lymphoma: A Mini-Review |
| title_sort | epidemiology and pathogenesis of nasal nk t cell lymphoma a mini review |
| url | http://dx.doi.org/10.1100/tsw.2011.41 |
| work_keys_str_mv | AT katsuyukiaozasa epidemiologyandpathogenesisofnasalnktcelllymphomaaminireview AT monaaazaki epidemiologyandpathogenesisofnasalnktcelllymphomaaminireview |