Canadian Public Health Laboratory Network laboratory Guidelines for the Use of Point-of-Care Tests for the Diagnosis of Syphilis in Canada
Syphilis point-of-care tests (POCT) are widely available in developing countries enabling early diagnosis, treatment and support. The majority of commercially available tests use treponemal antigens and the presence of antibodies does not distinguish between current and past infection, which may lea...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2015/152039 |
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| author | Ameeta E Singh Max A Chernesky Muhammad Morshed Tom Wong |
| author_facet | Ameeta E Singh Max A Chernesky Muhammad Morshed Tom Wong |
| author_sort | Ameeta E Singh |
| collection | DOAJ |
| description | Syphilis point-of-care tests (POCT) are widely available in developing countries enabling early diagnosis, treatment and support. The majority of commercially available tests use treponemal antigens and the presence of antibodies does not distinguish between current and past infection, which may lead to unnecessary antibiotic use and stigmatization of having a current STI. In hard-to-reach populations, the benefits may outweigh the risks. Available studies show reasonable performance of POCT with median sensitivity of 86%, specificity of 99% and positive predictive values >80% when prevalence was >0.3%. Although no syphilis POCT are approved in Canada at this time, a single study in an outreach setting in Alberta showed limited benefit due to a high prevalence of previous infection but more studies are needed. Newer dual tests employing treponemal and nontreponemal antigens look promising. |
| format | Article |
| id | doaj-art-cab68ec3b6144d40bdbf0dc7c909e5f4 |
| institution | Kabale University |
| issn | 1712-9532 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-cab68ec3b6144d40bdbf0dc7c909e5f42025-02-03T01:26:40ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322015-01-0126Supplement A29A32A10.1155/2015/152039Canadian Public Health Laboratory Network laboratory Guidelines for the Use of Point-of-Care Tests for the Diagnosis of Syphilis in CanadaAmeeta E Singh0Max A Chernesky1Muhammad Morshed2Tom Wong3Division of Infectious Diseases, University of Alberta, Edmonton, Alberta, CanadaMcMaster University, Hamilton, Ontario, CanadaBC Public Health Microbiology and Reference Laboratory, University of British Columbia, Vancouver, British Columbia, CanadaPublic Health Agency of Canada, Ottawa, Ontario, CanadaSyphilis point-of-care tests (POCT) are widely available in developing countries enabling early diagnosis, treatment and support. The majority of commercially available tests use treponemal antigens and the presence of antibodies does not distinguish between current and past infection, which may lead to unnecessary antibiotic use and stigmatization of having a current STI. In hard-to-reach populations, the benefits may outweigh the risks. Available studies show reasonable performance of POCT with median sensitivity of 86%, specificity of 99% and positive predictive values >80% when prevalence was >0.3%. Although no syphilis POCT are approved in Canada at this time, a single study in an outreach setting in Alberta showed limited benefit due to a high prevalence of previous infection but more studies are needed. Newer dual tests employing treponemal and nontreponemal antigens look promising.http://dx.doi.org/10.1155/2015/152039 |
| spellingShingle | Ameeta E Singh Max A Chernesky Muhammad Morshed Tom Wong Canadian Public Health Laboratory Network laboratory Guidelines for the Use of Point-of-Care Tests for the Diagnosis of Syphilis in Canada Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Canadian Public Health Laboratory Network laboratory Guidelines for the Use of Point-of-Care Tests for the Diagnosis of Syphilis in Canada |
| title_full | Canadian Public Health Laboratory Network laboratory Guidelines for the Use of Point-of-Care Tests for the Diagnosis of Syphilis in Canada |
| title_fullStr | Canadian Public Health Laboratory Network laboratory Guidelines for the Use of Point-of-Care Tests for the Diagnosis of Syphilis in Canada |
| title_full_unstemmed | Canadian Public Health Laboratory Network laboratory Guidelines for the Use of Point-of-Care Tests for the Diagnosis of Syphilis in Canada |
| title_short | Canadian Public Health Laboratory Network laboratory Guidelines for the Use of Point-of-Care Tests for the Diagnosis of Syphilis in Canada |
| title_sort | canadian public health laboratory network laboratory guidelines for the use of point of care tests for the diagnosis of syphilis in canada |
| url | http://dx.doi.org/10.1155/2015/152039 |
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