Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma
Tumor lysis syndrome (TLS) is an oncological emergency caused by massive cytolysis of malignant cells. This syndrome eventually induces metabolic abnormalities. TLS is observed mainly among tumors with rapid cell proliferation or high sensitivity to antineoplastic treatment. In rare cases, TLS occur...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/5103145 |
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| author | Shinichi Harada Keiki Nagaharu Youichirou Baba Tetsuya Murata Toshiro Mizuno Keiki Kawakami |
| author_facet | Shinichi Harada Keiki Nagaharu Youichirou Baba Tetsuya Murata Toshiro Mizuno Keiki Kawakami |
| author_sort | Shinichi Harada |
| collection | DOAJ |
| description | Tumor lysis syndrome (TLS) is an oncological emergency caused by massive cytolysis of malignant cells. This syndrome eventually induces metabolic abnormalities. TLS is observed mainly among tumors with rapid cell proliferation or high sensitivity to antineoplastic treatment. In rare cases, TLS occurs without any cytotoxic treatment. Previous reports have shown that alternative stress including proceeding infection or an operation might play a role in TLS. However, exact mechanism of spontaneous TLS remains unknown. Here, we describe a case of a 59-year-old woman who presented with dedifferentiated endometrial adenocarcinoma and developed TLS without any cytotoxic chemotherapy. Although spontaneous TLS in solid malignancies are extremely rare, clinicians should consider the possibilities of TLS especially in aggressive solid tumors. |
| format | Article |
| id | doaj-art-cab252c9d29642729f69ad694f31c18c |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-cab252c9d29642729f69ad694f31c18c2025-02-03T06:05:05ZengWileyCase Reports in Oncological Medicine2090-67062090-67142017-01-01201710.1155/2017/51031455103145Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial AdenocarcinomaShinichi Harada0Keiki Nagaharu1Youichirou Baba2Tetsuya Murata3Toshiro Mizuno4Keiki Kawakami5Department of Hematology and Oncology, Suzuka General Hospital, Yamanohana 1275-53, Suzuka, Mie Prefecture 513-8630, JapanDepartment of Hematology and Oncology, Suzuka General Hospital, Yamanohana 1275-53, Suzuka, Mie Prefecture 513-8630, JapanDepartment of Pathology, Suzuka General Hospital, Yamanohana 1275-53, Suzuka, Mie Prefecture 513-8630, JapanDepartment of Pathology, Suzuka General Hospital, Yamanohana 1275-53, Suzuka, Mie Prefecture 513-8630, JapanDepartment of Hematology and Oncology, Mie University Hospital, Edobashi 2-174, Tsu, Mie Prefecture 514-0001, JapanDepartment of Hematology and Oncology, Suzuka General Hospital, Yamanohana 1275-53, Suzuka, Mie Prefecture 513-8630, JapanTumor lysis syndrome (TLS) is an oncological emergency caused by massive cytolysis of malignant cells. This syndrome eventually induces metabolic abnormalities. TLS is observed mainly among tumors with rapid cell proliferation or high sensitivity to antineoplastic treatment. In rare cases, TLS occurs without any cytotoxic treatment. Previous reports have shown that alternative stress including proceeding infection or an operation might play a role in TLS. However, exact mechanism of spontaneous TLS remains unknown. Here, we describe a case of a 59-year-old woman who presented with dedifferentiated endometrial adenocarcinoma and developed TLS without any cytotoxic chemotherapy. Although spontaneous TLS in solid malignancies are extremely rare, clinicians should consider the possibilities of TLS especially in aggressive solid tumors.http://dx.doi.org/10.1155/2017/5103145 |
| spellingShingle | Shinichi Harada Keiki Nagaharu Youichirou Baba Tetsuya Murata Toshiro Mizuno Keiki Kawakami Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma Case Reports in Oncological Medicine |
| title | Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma |
| title_full | Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma |
| title_fullStr | Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma |
| title_full_unstemmed | Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma |
| title_short | Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma |
| title_sort | spontaneous tumor lysis syndrome in a patient with a dedifferentiated endometrial adenocarcinoma |
| url | http://dx.doi.org/10.1155/2017/5103145 |
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