Arsenic inducible islet β-cell dysfunction and ferroptosis through m6A-YTHDF2-dependent CHAC1 enhancement

Arsenic inducible islet β-cell dysfunction and ferroptosis through m6A-YTHDF2-dependent CHAC1 enhancement

Arsenic, recognized as an environmental and food contaminant, has been linked to the dysfunction of islet β-cells, the primary lesions in type 2 diabetes (T2D). Ferroptosis, a regulated cell death pathway dependent on GPX4, has been implicated in arsenic-induced β-cell dysfunction. However, the unde...

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Bibliographic Details
Main Authors: Tianming Qiu, Jingyuan Zhang, Jinwei Song, Chenbing Wu, Xiaofeng Yao, Ningning Wang, Guang Yang, Jie Bai, Li Lv, Xiance Sun
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Arsenic
β-cell
Ferroptosis
CHAC1
N6-methyladenosine
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324015550
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