A Study on Effect of Melatonin in Dyslipidemia Caused by Experimentally Diabetes
In this study, it was aimed to determine the effects of melatonin application on lipid profile in streptozotocin-induced diabetic rats. Animals in control group were not any treatment. Melatonin group animals received 50 mg/kg melatonin intraperitoneally in daily for eight weeks. Diabetes was induce...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2019-04-01
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| Series: | Türk Spor ve Egzersiz Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/710675 |
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| author | Deniz Uluışık Ercan Keskin Durmuş Hatipoğlu |
| author_facet | Deniz Uluışık Ercan Keskin Durmuş Hatipoğlu |
| author_sort | Deniz Uluışık |
| collection | DOAJ |
| description | In this study, it was
aimed to determine the effects of melatonin application on lipid profile in streptozotocin-induced diabetic rats. Animals in control group were not any
treatment. Melatonin group animals received 50 mg/kg melatonin
intraperitoneally in daily for eight weeks. Diabetes was induced by
subcutaneous injections of streptozotocin at dose of 40 mg/kg for two days as a
single dose per day in diabetes group animals. Animals in Diabetes+Melatonin
group were made diabetic by streptozotocin
in the same way and then these animals received 50 mg/kg melatonin
intraperitoneally in daily for eight weeks. In blood samples taken from all animals, TNF-α,
triglyceride, total cholesterol, LDL and HDL were determined. In diabetes
group, TNF-α level were high (p lt;0.05). The changes in TNF-α level with
melatonin application to diabetic rats were important (p lt;0.05). In diabetic
rats, triglyceride and LDL levels were found to be enhanced compared to control
group (p lt;0.05), HDL level was significantly low (p lt;0.05), while the
change in total cholesterol level was not important. With the melatonin
application to diabetic rats, HDL level was found to be higher (p lt;0.05) and
LDL level was lower than diabetes group (p lt;0.05). It was concluded that the
administration of melatonin to streptozotocin-induced diabetic rats may have positive effects on lipid profile. |
| format | Article |
| id | doaj-art-caaf655de68047d4bbaa79341516c6e9 |
| institution | Kabale University |
| issn | 2147-5652 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Türk Spor ve Egzersiz Dergisi |
| spelling | doaj-art-caaf655de68047d4bbaa79341516c6e92025-02-03T03:38:45ZengSelcuk University PressTürk Spor ve Egzersiz Dergisi2147-56522019-04-0121111712110.15314/tsed.541834154A Study on Effect of Melatonin in Dyslipidemia Caused by Experimentally DiabetesDeniz Uluışık0Ercan Keskin1Durmuş Hatipoğlu2SELÇUK ÜNİVERSİTESİ, VETERİNER FAKÜLTESİSELÇUK ÜNİVERSİTESİ, VETERİNER FAKÜLTESİSELÇUK ÜNİVERSİTESİ, VETERİNER FAKÜLTESİIn this study, it was aimed to determine the effects of melatonin application on lipid profile in streptozotocin-induced diabetic rats. Animals in control group were not any treatment. Melatonin group animals received 50 mg/kg melatonin intraperitoneally in daily for eight weeks. Diabetes was induced by subcutaneous injections of streptozotocin at dose of 40 mg/kg for two days as a single dose per day in diabetes group animals. Animals in Diabetes+Melatonin group were made diabetic by streptozotocin in the same way and then these animals received 50 mg/kg melatonin intraperitoneally in daily for eight weeks. In blood samples taken from all animals, TNF-α, triglyceride, total cholesterol, LDL and HDL were determined. In diabetes group, TNF-α level were high (p lt;0.05). The changes in TNF-α level with melatonin application to diabetic rats were important (p lt;0.05). In diabetic rats, triglyceride and LDL levels were found to be enhanced compared to control group (p lt;0.05), HDL level was significantly low (p lt;0.05), while the change in total cholesterol level was not important. With the melatonin application to diabetic rats, HDL level was found to be higher (p lt;0.05) and LDL level was lower than diabetes group (p lt;0.05). It was concluded that the administration of melatonin to streptozotocin-induced diabetic rats may have positive effects on lipid profile.https://dergipark.org.tr/tr/download/article-file/710675diabetesmelatonintnf-αlipid profile |
| spellingShingle | Deniz Uluışık Ercan Keskin Durmuş Hatipoğlu A Study on Effect of Melatonin in Dyslipidemia Caused by Experimentally Diabetes Türk Spor ve Egzersiz Dergisi diabetes melatonin tnf-α lipid profile |
| title | A Study on Effect of Melatonin in Dyslipidemia Caused by Experimentally Diabetes |
| title_full | A Study on Effect of Melatonin in Dyslipidemia Caused by Experimentally Diabetes |
| title_fullStr | A Study on Effect of Melatonin in Dyslipidemia Caused by Experimentally Diabetes |
| title_full_unstemmed | A Study on Effect of Melatonin in Dyslipidemia Caused by Experimentally Diabetes |
| title_short | A Study on Effect of Melatonin in Dyslipidemia Caused by Experimentally Diabetes |
| title_sort | study on effect of melatonin in dyslipidemia caused by experimentally diabetes |
| topic | diabetes melatonin tnf-α lipid profile |
| url | https://dergipark.org.tr/tr/download/article-file/710675 |
| work_keys_str_mv | AT denizuluısık astudyoneffectofmelatoninindyslipidemiacausedbyexperimentallydiabetes AT ercankeskin astudyoneffectofmelatoninindyslipidemiacausedbyexperimentallydiabetes AT durmushatipoglu astudyoneffectofmelatoninindyslipidemiacausedbyexperimentallydiabetes AT denizuluısık studyoneffectofmelatoninindyslipidemiacausedbyexperimentallydiabetes AT ercankeskin studyoneffectofmelatoninindyslipidemiacausedbyexperimentallydiabetes AT durmushatipoglu studyoneffectofmelatoninindyslipidemiacausedbyexperimentallydiabetes |