Immune Response in Ovarian Cancer: How Is the Immune System Involved in Prognosis and Therapy: Potential for Treatment Utilization
Ovarian cancer is one of the leading causes of cancer-related death among women. Resistance to the disease occurs in more than 70% of the cases even after treated with chemotherapy agents such as paclitaxel- and platinum-based agents. The immune system is increasingly becoming a target for intense r...
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Format: | Article |
Language: | English |
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Wiley
2010-01-01
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Series: | Clinical and Developmental Immunology |
Online Access: | http://dx.doi.org/10.1155/2010/791603 |
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author | Nikos G. Gavalas Alexandra Karadimou Meletios A. Dimopoulos Aristotelis Bamias |
author_facet | Nikos G. Gavalas Alexandra Karadimou Meletios A. Dimopoulos Aristotelis Bamias |
author_sort | Nikos G. Gavalas |
collection | DOAJ |
description | Ovarian cancer is one of the leading causes of cancer-related death among women. Resistance to the disease occurs in more than 70% of the cases even after treated with chemotherapy agents such as paclitaxel- and platinum-based agents. The immune system is increasingly becoming a target for intense research in order to study the host's immune response against ovarian cancer. T cell populations, including NK T cells and Tregs, and cytokines have been associated with disease outcome, indicating their increasing clinical significance, having been associated with prognosis and as markers of disease progress, respectively. Harnessing the immune system capacity in order to induce antitumor response remains a major challenge.
This paper examines the recent developments in our understanding of the mechanisms of development of the immune response in ovarian cancer as well as its prognostic significance and the existing experience in clinical studies. |
format | Article |
id | doaj-art-caae8fbc89c04361b31f2d742bac7c22 |
institution | Kabale University |
issn | 1740-2522 1740-2530 |
language | English |
publishDate | 2010-01-01 |
publisher | Wiley |
record_format | Article |
series | Clinical and Developmental Immunology |
spelling | doaj-art-caae8fbc89c04361b31f2d742bac7c222025-02-03T06:08:36ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/791603791603Immune Response in Ovarian Cancer: How Is the Immune System Involved in Prognosis and Therapy: Potential for Treatment UtilizationNikos G. Gavalas0Alexandra Karadimou1Meletios A. Dimopoulos2Aristotelis Bamias3Department of Clinical Therapeutics, Medical School, University of Athens, Alexandra Hospital, 80 Vasilissis Sofias Avenue, 115 28 Athens, GreeceDepartment of Clinical Therapeutics, Medical School, University of Athens, Alexandra Hospital, 80 Vasilissis Sofias Avenue, 115 28 Athens, GreeceDepartment of Clinical Therapeutics, Medical School, University of Athens, Alexandra Hospital, 80 Vasilissis Sofias Avenue, 115 28 Athens, GreeceDepartment of Clinical Therapeutics, Medical School, University of Athens, Alexandra Hospital, 80 Vasilissis Sofias Avenue, 115 28 Athens, GreeceOvarian cancer is one of the leading causes of cancer-related death among women. Resistance to the disease occurs in more than 70% of the cases even after treated with chemotherapy agents such as paclitaxel- and platinum-based agents. The immune system is increasingly becoming a target for intense research in order to study the host's immune response against ovarian cancer. T cell populations, including NK T cells and Tregs, and cytokines have been associated with disease outcome, indicating their increasing clinical significance, having been associated with prognosis and as markers of disease progress, respectively. Harnessing the immune system capacity in order to induce antitumor response remains a major challenge. This paper examines the recent developments in our understanding of the mechanisms of development of the immune response in ovarian cancer as well as its prognostic significance and the existing experience in clinical studies.http://dx.doi.org/10.1155/2010/791603 |
spellingShingle | Nikos G. Gavalas Alexandra Karadimou Meletios A. Dimopoulos Aristotelis Bamias Immune Response in Ovarian Cancer: How Is the Immune System Involved in Prognosis and Therapy: Potential for Treatment Utilization Clinical and Developmental Immunology |
title | Immune Response in Ovarian Cancer: How Is the Immune System Involved in Prognosis and Therapy: Potential for Treatment Utilization |
title_full | Immune Response in Ovarian Cancer: How Is the Immune System Involved in Prognosis and Therapy: Potential for Treatment Utilization |
title_fullStr | Immune Response in Ovarian Cancer: How Is the Immune System Involved in Prognosis and Therapy: Potential for Treatment Utilization |
title_full_unstemmed | Immune Response in Ovarian Cancer: How Is the Immune System Involved in Prognosis and Therapy: Potential for Treatment Utilization |
title_short | Immune Response in Ovarian Cancer: How Is the Immune System Involved in Prognosis and Therapy: Potential for Treatment Utilization |
title_sort | immune response in ovarian cancer how is the immune system involved in prognosis and therapy potential for treatment utilization |
url | http://dx.doi.org/10.1155/2010/791603 |
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