Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease
Background. Visuospatial dysfunction is among the first cognitive symptoms in Parkinson’s disease (PD) and is often predictive for PD-dementia. Furthermore, cognitive status in PD-patients correlates with quantitative EEG. This cross-sectional study aimed to investigate the correlation between EEG s...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2017/3659784 |
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| author | Dominique Eichelberger Pasquale Calabrese Antonia Meyer Menorca Chaturvedi Florian Hatz Peter Fuhr Ute Gschwandtner |
| author_facet | Dominique Eichelberger Pasquale Calabrese Antonia Meyer Menorca Chaturvedi Florian Hatz Peter Fuhr Ute Gschwandtner |
| author_sort | Dominique Eichelberger |
| collection | DOAJ |
| description | Background. Visuospatial dysfunction is among the first cognitive symptoms in Parkinson’s disease (PD) and is often predictive for PD-dementia. Furthermore, cognitive status in PD-patients correlates with quantitative EEG. This cross-sectional study aimed to investigate the correlation between EEG slowing and visuospatial ability in nondemented PD-patients. Methods. Fifty-seven nondemented PD-patients (17 females/40 males) were evaluated with a comprehensive neuropsychological test battery and a high-resolution 256-channel EEG was recorded. A median split was performed for each cognitive test dividing the patients sample into either a normal or lower performance group. The electrodes were split into five areas: frontal, central, temporal, parietal, and occipital. A linear mixed effects model (LME) was used for correlational analyses and to control for confounding factors. Results. Subsequently, for the lower performance, LME analysis showed a significant positive correlation between ROCF score and parietal alpha/theta ratio (b=.59, p=.012) and occipital alpha/theta ratio (b=0.50, p=.030). No correlations were found in the group of patients with normal visuospatial abilities. Conclusion. We conclude that a reduction of the parietal alpha/theta ratio is related to visuospatial impairments in PD-patients. These findings indicate that visuospatial impairment in PD-patients could be influenced by parietal dysfunction. |
| format | Article |
| id | doaj-art-caa970bcf1c749b0bccb0fee492fd79e |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-caa970bcf1c749b0bccb0fee492fd79e2025-02-03T01:03:31ZengWileyParkinson's Disease2090-80832042-00802017-01-01201710.1155/2017/36597843659784Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s DiseaseDominique Eichelberger0Pasquale Calabrese1Antonia Meyer2Menorca Chaturvedi3Florian Hatz4Peter Fuhr5Ute Gschwandtner6Division of Molecular and Cognitive Neuroscience, Neuropsychology and Behavioural Neurology Unit, University of Basel, Basel, SwitzerlandDivision of Molecular and Cognitive Neuroscience, Neuropsychology and Behavioural Neurology Unit, University of Basel, Basel, SwitzerlandDepartment of Neurology, Hospital of the University of Basel, Petersgraben 4, 4031 Basel, SwitzerlandDepartment of Neurology, Hospital of the University of Basel, Petersgraben 4, 4031 Basel, SwitzerlandDepartment of Neurology, Hospital of the University of Basel, Petersgraben 4, 4031 Basel, SwitzerlandDepartment of Neurology, Hospital of the University of Basel, Petersgraben 4, 4031 Basel, SwitzerlandDepartment of Neurology, Hospital of the University of Basel, Petersgraben 4, 4031 Basel, SwitzerlandBackground. Visuospatial dysfunction is among the first cognitive symptoms in Parkinson’s disease (PD) and is often predictive for PD-dementia. Furthermore, cognitive status in PD-patients correlates with quantitative EEG. This cross-sectional study aimed to investigate the correlation between EEG slowing and visuospatial ability in nondemented PD-patients. Methods. Fifty-seven nondemented PD-patients (17 females/40 males) were evaluated with a comprehensive neuropsychological test battery and a high-resolution 256-channel EEG was recorded. A median split was performed for each cognitive test dividing the patients sample into either a normal or lower performance group. The electrodes were split into five areas: frontal, central, temporal, parietal, and occipital. A linear mixed effects model (LME) was used for correlational analyses and to control for confounding factors. Results. Subsequently, for the lower performance, LME analysis showed a significant positive correlation between ROCF score and parietal alpha/theta ratio (b=.59, p=.012) and occipital alpha/theta ratio (b=0.50, p=.030). No correlations were found in the group of patients with normal visuospatial abilities. Conclusion. We conclude that a reduction of the parietal alpha/theta ratio is related to visuospatial impairments in PD-patients. These findings indicate that visuospatial impairment in PD-patients could be influenced by parietal dysfunction.http://dx.doi.org/10.1155/2017/3659784 |
| spellingShingle | Dominique Eichelberger Pasquale Calabrese Antonia Meyer Menorca Chaturvedi Florian Hatz Peter Fuhr Ute Gschwandtner Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease Parkinson's Disease |
| title | Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease |
| title_full | Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease |
| title_fullStr | Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease |
| title_full_unstemmed | Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease |
| title_short | Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease |
| title_sort | correlation of visuospatial ability and eeg slowing in patients with parkinson s disease |
| url | http://dx.doi.org/10.1155/2017/3659784 |
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