Chinese Herbal Medicine for Weight Management: A Systematic Review and Meta-Analyses of Randomised Controlled Trials
Objective. This review investigated the effects and safety of Chinese herbal medicine (CHM) formulas on weight management. Methods. Eighteen databases in English, Chinese, Korean, and Japanese were searched from their inceptions to September 2019. The treatment groups included CHM formulations, and...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2021/3250723 |
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| _version_ | 1832561593687212032 |
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| author | Ann Rann Wong Angela Wei Hong Yang Kangxiao Li Harsharn Gill Mingdi Li George Binh Lenon |
| author_facet | Ann Rann Wong Angela Wei Hong Yang Kangxiao Li Harsharn Gill Mingdi Li George Binh Lenon |
| author_sort | Ann Rann Wong |
| collection | DOAJ |
| description | Objective. This review investigated the effects and safety of Chinese herbal medicine (CHM) formulas on weight management. Methods. Eighteen databases in English, Chinese, Korean, and Japanese were searched from their inceptions to September 2019. The treatment groups included CHM formulations, and the control included placebo, Western medication (WM), and lifestyle intervention (LI), with or without cointerventions (WM and/or LI). Quality of studies was assessed using Cochrane Collaboration’s risk of bias assessment tool. Body weight and body mass index (BMI) were analysed in RevMan v5.4.1 and expressed as mean differences with 95% confidence intervals (CI), while adverse events were expressed as risk ratio with 95% CI. Results. Thirty-nine RCTs were eligible for qualitative analysis, 34 of which were included in the meta-analyses. The majority of studies had a high or unclear risk of selection, performance, and detection bias. Twenty-five CHM studies involving cointerventions revealed that CHM had significant adjunct effects on body weight and BMI at the end of treatment compared to control. No serious adverse events were reported in the CHM groups. Conclusion. CHM indicates a promising adjunct to facilitate WM or lifestyle change for weight management. However, methodological barriers such as lack of allocation concealment and double-blinding may have led to challenges in data synthesis. More rigorously designed RCTs involving cointerventions are warranted. |
| format | Article |
| id | doaj-art-ca9efd563f414fa7a7a510ab7b587bbd |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-ca9efd563f414fa7a7a510ab7b587bbd2025-02-03T01:24:38ZengWileyJournal of Obesity2090-07082090-07162021-01-01202110.1155/2021/32507233250723Chinese Herbal Medicine for Weight Management: A Systematic Review and Meta-Analyses of Randomised Controlled TrialsAnn Rann Wong0Angela Wei Hong Yang1Kangxiao Li2Harsharn Gill3Mingdi Li4George Binh Lenon5School of Health and Biomedical Sciences, RMIT University Bundoora, VIC, AustraliaSchool of Health and Biomedical Sciences, RMIT University Bundoora, VIC, AustraliaSchool of Health and Biomedical Sciences, RMIT University Bundoora, VIC, AustraliaSchool of Science, RMIT University, Melbourne VIC, AustraliaSchool of Health and Biomedical Sciences, RMIT University Bundoora, VIC, AustraliaSchool of Health and Biomedical Sciences, RMIT University Bundoora, VIC, AustraliaObjective. This review investigated the effects and safety of Chinese herbal medicine (CHM) formulas on weight management. Methods. Eighteen databases in English, Chinese, Korean, and Japanese were searched from their inceptions to September 2019. The treatment groups included CHM formulations, and the control included placebo, Western medication (WM), and lifestyle intervention (LI), with or without cointerventions (WM and/or LI). Quality of studies was assessed using Cochrane Collaboration’s risk of bias assessment tool. Body weight and body mass index (BMI) were analysed in RevMan v5.4.1 and expressed as mean differences with 95% confidence intervals (CI), while adverse events were expressed as risk ratio with 95% CI. Results. Thirty-nine RCTs were eligible for qualitative analysis, 34 of which were included in the meta-analyses. The majority of studies had a high or unclear risk of selection, performance, and detection bias. Twenty-five CHM studies involving cointerventions revealed that CHM had significant adjunct effects on body weight and BMI at the end of treatment compared to control. No serious adverse events were reported in the CHM groups. Conclusion. CHM indicates a promising adjunct to facilitate WM or lifestyle change for weight management. However, methodological barriers such as lack of allocation concealment and double-blinding may have led to challenges in data synthesis. More rigorously designed RCTs involving cointerventions are warranted.http://dx.doi.org/10.1155/2021/3250723 |
| spellingShingle | Ann Rann Wong Angela Wei Hong Yang Kangxiao Li Harsharn Gill Mingdi Li George Binh Lenon Chinese Herbal Medicine for Weight Management: A Systematic Review and Meta-Analyses of Randomised Controlled Trials Journal of Obesity |
| title | Chinese Herbal Medicine for Weight Management: A Systematic Review and Meta-Analyses of Randomised Controlled Trials |
| title_full | Chinese Herbal Medicine for Weight Management: A Systematic Review and Meta-Analyses of Randomised Controlled Trials |
| title_fullStr | Chinese Herbal Medicine for Weight Management: A Systematic Review and Meta-Analyses of Randomised Controlled Trials |
| title_full_unstemmed | Chinese Herbal Medicine for Weight Management: A Systematic Review and Meta-Analyses of Randomised Controlled Trials |
| title_short | Chinese Herbal Medicine for Weight Management: A Systematic Review and Meta-Analyses of Randomised Controlled Trials |
| title_sort | chinese herbal medicine for weight management a systematic review and meta analyses of randomised controlled trials |
| url | http://dx.doi.org/10.1155/2021/3250723 |
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