Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of OATF against kidney stones

Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of OATF against kidney stones

IntroductionOrthosiphon aristatus (Blume) Miq. (OA) is widely used in folk medicine to treat kidney stones (KS). Its total flavonoids (OATF) are the primary active constituents responsible for its therapeutic effects. However, the exact mechanism of action (MOA) remains unclear. This study aimed to...

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Bibliographic Details
Main Authors: Sisi Dai, Qi Fang, Hong-Yan Li, Rui Sun, Hui-Yong Zhang, Wei Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
Orthosiphon aristatus
kidney stone
apoptosis
network pharmacology
EGFR/PI3K/Akt
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1575270/full
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