Fractional-Order Modeling of Arterial Compliance in Vascular Aging: A Computational Biomechanical Approach for Investigating Cardiovascular Dynamics
<italic>Goal:</italic> The goal of this study is to investigate the application of fractional-order calculus in modeling arterial compliance in human vascular aging. <italic>Methods:</italic> A novel fractional-order modified arterial Windkessel model that incorporates a frac...
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| Format: | Article |
| Language: | English |
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IEEE
2024-01-01
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| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
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| Online Access: | https://ieeexplore.ieee.org/document/10360232/ |
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| author | Mohamed A. Bahloul Yasser Aboelkassem Zehor Belkhatir Taous-Meriem Laleg-Kirati |
| author_facet | Mohamed A. Bahloul Yasser Aboelkassem Zehor Belkhatir Taous-Meriem Laleg-Kirati |
| author_sort | Mohamed A. Bahloul |
| collection | DOAJ |
| description | <italic>Goal:</italic> The goal of this study is to investigate the application of fractional-order calculus in modeling arterial compliance in human vascular aging. <italic>Methods:</italic> A novel fractional-order modified arterial Windkessel model that incorporates a fractional-order capacitor (FOC) element is proposed to capture the complex and frequency-dependent properties of arterial compliance. The model's performance is evaluated by verifying it using data collected from three different human subjects, with a specific focus on aortic pressure and flow rates. <italic>Results:</italic> The results show that the FOC model accurately captures the dynamics of arterial compliance, providing a flexible means to estimate central blood pressure distribution and arterial stiffness. <italic>Conclusions:</italic> This study demonstrates the potential of fractional-order calculus in advancing the modeling and characterization of arterial compliance in human vascular aging. The proposed FOC model can improve our understanding of the physiological changes in arterial compliance associated with aging and help to identify potential interventions for age-related cardiovascular diseases. |
| format | Article |
| id | doaj-art-ca925f6c915e40448174a6f4d69a6fed |
| institution | Kabale University |
| issn | 2644-1276 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj-art-ca925f6c915e40448174a6f4d69a6fed2025-01-28T00:02:10ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762024-01-01565066010.1109/OJEMB.2023.334308310360232Fractional-Order Modeling of Arterial Compliance in Vascular Aging: A Computational Biomechanical Approach for Investigating Cardiovascular DynamicsMohamed A. Bahloul0https://orcid.org/0000-0002-4510-8029Yasser Aboelkassem1https://orcid.org/0000-0002-4993-4141Zehor Belkhatir2https://orcid.org/0000-0001-7277-3895Taous-Meriem Laleg-Kirati3https://orcid.org/0000-0001-5944-0121Electrical Engineering Department, College of Engineering, Alfaisal University, Riyadh, Saudi ArabiaCollege of Innovation and Technology, University of Michigan, Flint, MI, USADigital Health & Biomedical Engineering Group, School of Electronics and Computer Science, University of Southampton, Southampton, U.K.Computer, Electrical and Mathematical Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Makkah, Saudi Arabia<italic>Goal:</italic> The goal of this study is to investigate the application of fractional-order calculus in modeling arterial compliance in human vascular aging. <italic>Methods:</italic> A novel fractional-order modified arterial Windkessel model that incorporates a fractional-order capacitor (FOC) element is proposed to capture the complex and frequency-dependent properties of arterial compliance. The model's performance is evaluated by verifying it using data collected from three different human subjects, with a specific focus on aortic pressure and flow rates. <italic>Results:</italic> The results show that the FOC model accurately captures the dynamics of arterial compliance, providing a flexible means to estimate central blood pressure distribution and arterial stiffness. <italic>Conclusions:</italic> This study demonstrates the potential of fractional-order calculus in advancing the modeling and characterization of arterial compliance in human vascular aging. The proposed FOC model can improve our understanding of the physiological changes in arterial compliance associated with aging and help to identify potential interventions for age-related cardiovascular diseases.https://ieeexplore.ieee.org/document/10360232/Fractional calculusfractional-order capacitorvascular complianceaortic input impedance |
| spellingShingle | Mohamed A. Bahloul Yasser Aboelkassem Zehor Belkhatir Taous-Meriem Laleg-Kirati Fractional-Order Modeling of Arterial Compliance in Vascular Aging: A Computational Biomechanical Approach for Investigating Cardiovascular Dynamics IEEE Open Journal of Engineering in Medicine and Biology Fractional calculus fractional-order capacitor vascular compliance aortic input impedance |
| title | Fractional-Order Modeling of Arterial Compliance in Vascular Aging: A Computational Biomechanical Approach for Investigating Cardiovascular Dynamics |
| title_full | Fractional-Order Modeling of Arterial Compliance in Vascular Aging: A Computational Biomechanical Approach for Investigating Cardiovascular Dynamics |
| title_fullStr | Fractional-Order Modeling of Arterial Compliance in Vascular Aging: A Computational Biomechanical Approach for Investigating Cardiovascular Dynamics |
| title_full_unstemmed | Fractional-Order Modeling of Arterial Compliance in Vascular Aging: A Computational Biomechanical Approach for Investigating Cardiovascular Dynamics |
| title_short | Fractional-Order Modeling of Arterial Compliance in Vascular Aging: A Computational Biomechanical Approach for Investigating Cardiovascular Dynamics |
| title_sort | fractional order modeling of arterial compliance in vascular aging a computational biomechanical approach for investigating cardiovascular dynamics |
| topic | Fractional calculus fractional-order capacitor vascular compliance aortic input impedance |
| url | https://ieeexplore.ieee.org/document/10360232/ |
| work_keys_str_mv | AT mohamedabahloul fractionalordermodelingofarterialcomplianceinvascularagingacomputationalbiomechanicalapproachforinvestigatingcardiovasculardynamics AT yasseraboelkassem fractionalordermodelingofarterialcomplianceinvascularagingacomputationalbiomechanicalapproachforinvestigatingcardiovasculardynamics AT zehorbelkhatir fractionalordermodelingofarterialcomplianceinvascularagingacomputationalbiomechanicalapproachforinvestigatingcardiovasculardynamics AT taousmeriemlalegkirati fractionalordermodelingofarterialcomplianceinvascularagingacomputationalbiomechanicalapproachforinvestigatingcardiovasculardynamics |