Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function
Increased interest in the pathogenesis and the evolution of autoimmune chronic atrophic gastritis (A-CAG) has led to the search for serological markers that can be used to detect changes in the gastric mucosa at an early stage and to monitor the course of the disease. Parietal cell autoantibodies ha...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Journal of Translational Autoimmunity |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589909025000085 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586297808519168 |
|---|---|
| author | Maria Piera Panozzo Antonio Antico Nicola Bizzaro |
| author_facet | Maria Piera Panozzo Antonio Antico Nicola Bizzaro |
| author_sort | Maria Piera Panozzo |
| collection | DOAJ |
| description | Increased interest in the pathogenesis and the evolution of autoimmune chronic atrophic gastritis (A-CAG) has led to the search for serological markers that can be used to detect changes in the gastric mucosa at an early stage and to monitor the course of the disease. Parietal cell autoantibodies have been proposed as suitable immunological markers of atrophic damage, as they can be detected in the serum when symptoms of gastritis are not yet present. However, the utility of measuring only the level of parietal cell autoantibodies in the follow-up of A-CAG does not appear to suffice. Recent evidence has suggested that, in monitoring A-CAG, parietal cell antibodies should be associated with an evaluation of gastric function through biochemical and hormonal tests, such as pepsinogens and gastrin 17. This integrated approach will allow for the more effective real-time monitoring of the state of the gastric mucosa. As A-CAG is a progressive disorder associated with an increased risk of gastric cancer and neuroendocrine tumors, the precise follow-up of patients with gastric atrophy needs to be better defined. Further longitudinal studies in large cohorts must be performed with long-term follow-up. |
| format | Article |
| id | doaj-art-ca90a1c0bd1a41e09265bfd5b997cfe1 |
| institution | Kabale University |
| issn | 2589-9090 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Translational Autoimmunity |
| spelling | doaj-art-ca90a1c0bd1a41e09265bfd5b997cfe12025-01-26T05:04:43ZengElsevierJournal of Translational Autoimmunity2589-90902025-06-0110100273Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric functionMaria Piera Panozzo0Antonio Antico1Nicola Bizzaro2Department of Laboratory Medicine, AULSS7 Pedemontana, Santorso, ItalyDepartment of Laboratory Medicine, AULSS2 Marca Trevigiana, Treviso, ItalyLaboratory of Clinical Pathology, Azienda Sanitaria Universitaria Integrata, Udine, Italy; Corresponding author.Increased interest in the pathogenesis and the evolution of autoimmune chronic atrophic gastritis (A-CAG) has led to the search for serological markers that can be used to detect changes in the gastric mucosa at an early stage and to monitor the course of the disease. Parietal cell autoantibodies have been proposed as suitable immunological markers of atrophic damage, as they can be detected in the serum when symptoms of gastritis are not yet present. However, the utility of measuring only the level of parietal cell autoantibodies in the follow-up of A-CAG does not appear to suffice. Recent evidence has suggested that, in monitoring A-CAG, parietal cell antibodies should be associated with an evaluation of gastric function through biochemical and hormonal tests, such as pepsinogens and gastrin 17. This integrated approach will allow for the more effective real-time monitoring of the state of the gastric mucosa. As A-CAG is a progressive disorder associated with an increased risk of gastric cancer and neuroendocrine tumors, the precise follow-up of patients with gastric atrophy needs to be better defined. Further longitudinal studies in large cohorts must be performed with long-term follow-up.http://www.sciencedirect.com/science/article/pii/S2589909025000085Parietal cell autoantibodiesIntrinsic factor autoantibodiesAutoimmune chronic atrophic gastritisNeuroendocrine tumorsPepsinogensGastrin 17 |
| spellingShingle | Maria Piera Panozzo Antonio Antico Nicola Bizzaro Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function Journal of Translational Autoimmunity Parietal cell autoantibodies Intrinsic factor autoantibodies Autoimmune chronic atrophic gastritis Neuroendocrine tumors Pepsinogens Gastrin 17 |
| title | Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function |
| title_full | Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function |
| title_fullStr | Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function |
| title_full_unstemmed | Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function |
| title_short | Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function |
| title_sort | monitoring the follow up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function |
| topic | Parietal cell autoantibodies Intrinsic factor autoantibodies Autoimmune chronic atrophic gastritis Neuroendocrine tumors Pepsinogens Gastrin 17 |
| url | http://www.sciencedirect.com/science/article/pii/S2589909025000085 |
| work_keys_str_mv | AT mariapierapanozzo monitoringthefollowupofautoimmunechronicatrophicgastritisusingparietalcellantibodiesandmarkersofgastricfunction AT antonioantico monitoringthefollowupofautoimmunechronicatrophicgastritisusingparietalcellantibodiesandmarkersofgastricfunction AT nicolabizzaro monitoringthefollowupofautoimmunechronicatrophicgastritisusingparietalcellantibodiesandmarkersofgastricfunction |