c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells.

c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells.

Deregulation of Src kinases is associated with cancer. We previously showed that SrcDN conditional expression in MCF7 cells reduces tumorigenesis and causes tumor regression in mice. However, it remained unclear whether SrcDN affected breast cancer stem cell functionality or it reduced tumor mass. H...

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Bibliographic Details
Main Authors: Víctor Mayoral-Varo, Annarica Calcabrini, María Pilar Sánchez-Bailón, Óscar H Martínez-Costa, Cristina González-Páramos, Sergio Ciordia, David Hardisson, Juan J Aragón, Miguel Ángel Fernández-Moreno, Jorge Martín-Pérez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235850&type=printable
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