HGF/c-MET axis contributes to CLL cell survival by regulating multiple mechanisms making it a potential therapeutic target for CLL treatment

HGF/c-MET axis contributes to CLL cell survival by regulating multiple mechanisms making it a potential therapeutic target for CLL treatment

Despite significant advances in understanding the occurrence, progression and treatment of chronic lymphocytic leukemia (CLL), there remains a need to explore novel mechanisms and therapeutic strategies. In this study, we discovered that hepatocyte growth factor (HGF), a cytokine highly expressed by...

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Bibliographic Details
Main Authors: Shihao Liang, Xiaoya Shao, Xueqiong Meng, Ying Cui, Chuanyue Sun, Jie Sun, Binghui Zhang, Guomin Shen, Ling Qin, Haiping Yang, Yixiang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
chronic lymphocytic leukemia
HGF/c-Met
signaling pathway
anti-apoptotic proteins
capmatinib
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1612916/full
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