Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases
In recent years, there has been ample evidence illustrating the effect of microbiota on gut immunity, homeostasis, and disease. Most of these studies have engaged more efforts in understanding the role of the bacteriome in gut mucosal immunity and disease. However, studies on the virome and its infl...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/7883945 |
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| author | Njinju Asaba Clinton Sodiq Ayobami Hameed Eugene Kusi Agyei Joy Chinwendu Jacob Victor Oyewale Oyebanji Cyril Ekabe Jabea |
| author_facet | Njinju Asaba Clinton Sodiq Ayobami Hameed Eugene Kusi Agyei Joy Chinwendu Jacob Victor Oyewale Oyebanji Cyril Ekabe Jabea |
| author_sort | Njinju Asaba Clinton |
| collection | DOAJ |
| description | In recent years, there has been ample evidence illustrating the effect of microbiota on gut immunity, homeostasis, and disease. Most of these studies have engaged more efforts in understanding the role of the bacteriome in gut mucosal immunity and disease. However, studies on the virome and its influence on gut mucosal immunity and pathology are still at infancy owing to limited metagenomic tools. Nonetheless, the existing studies on the virome have largely been focused on the bacteriophages as these represent the main component of the virome with little information on endogenous retroviruses (ERVs) and eukaryotic viruses. In this review, we describe the gut virome, and its role in gut mucosal response and disease progression. We also explore the crosstalk between the virome and other microorganisms in the gut mucosa and elaborate on how these interactions shape the gut mucosal immunity going from bacteriophages through ERVs to eukaryotic viruses. Finally, we elucidate the potential contribution of this crosstalk in the pathogenesis of inflammatory bowel diseases and colon cancer. |
| format | Article |
| id | doaj-art-ca827480689844d6bc6041ac7f43abce |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-ca827480689844d6bc6041ac7f43abce2025-02-03T05:57:24ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/7883945Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and DiseasesNjinju Asaba Clinton0Sodiq Ayobami Hameed1Eugene Kusi Agyei2Joy Chinwendu Jacob3Victor Oyewale Oyebanji4Cyril Ekabe Jabea5Health and Empowerment FoundationUniv LyonFaculty of Pharmacy and Pharmaceutical SciencesUniv LyonUniv LyonHealth and Empowerment FoundationIn recent years, there has been ample evidence illustrating the effect of microbiota on gut immunity, homeostasis, and disease. Most of these studies have engaged more efforts in understanding the role of the bacteriome in gut mucosal immunity and disease. However, studies on the virome and its influence on gut mucosal immunity and pathology are still at infancy owing to limited metagenomic tools. Nonetheless, the existing studies on the virome have largely been focused on the bacteriophages as these represent the main component of the virome with little information on endogenous retroviruses (ERVs) and eukaryotic viruses. In this review, we describe the gut virome, and its role in gut mucosal response and disease progression. We also explore the crosstalk between the virome and other microorganisms in the gut mucosa and elaborate on how these interactions shape the gut mucosal immunity going from bacteriophages through ERVs to eukaryotic viruses. Finally, we elucidate the potential contribution of this crosstalk in the pathogenesis of inflammatory bowel diseases and colon cancer.http://dx.doi.org/10.1155/2022/7883945 |
| spellingShingle | Njinju Asaba Clinton Sodiq Ayobami Hameed Eugene Kusi Agyei Joy Chinwendu Jacob Victor Oyewale Oyebanji Cyril Ekabe Jabea Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases Journal of Immunology Research |
| title | Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases |
| title_full | Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases |
| title_fullStr | Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases |
| title_full_unstemmed | Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases |
| title_short | Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases |
| title_sort | crosstalk between the intestinal virome and other components of the microbiota and its effect on intestinal mucosal response and diseases |
| url | http://dx.doi.org/10.1155/2022/7883945 |
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