Neutrophil extracellular traps in tumor metabolism and microenvironment
Abstract Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array of physiological and pathological activities, including immune rheumatic diseases and damage...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Biomarker Research |
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| Online Access: | https://doi.org/10.1186/s40364-025-00731-z |
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| author | Zhanrui Liu Yuanyao Dou Conghua Lu Rui Han Yong He |
| author_facet | Zhanrui Liu Yuanyao Dou Conghua Lu Rui Han Yong He |
| author_sort | Zhanrui Liu |
| collection | DOAJ |
| description | Abstract Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array of physiological and pathological activities, including immune rheumatic diseases and damage to target organs. Recently, the connection between NETs and cancer has garnered significant attention. Within the tumor microenvironment and metabolism, NETs exhibit multifaceted roles, such as promoting the proliferation and migration of tumor cells, influencing redox balance, triggering angiogenesis, and driving metabolic reprogramming. This review offers a comprehensive analysis of the link between NETs and tumor metabolism, emphasizing areas that remain underexplored. These include the interaction of NETs with tumor mitochondria, their effect on redox states within tumors, their involvement in metabolic reprogramming, and their contribution to angiogenesis in tumors. Such insights lay a theoretical foundation for a deeper understanding of the role of NETs in cancer development. Moreover, the review also delves into potential therapeutic strategies that target NETs and suggests future research directions, offering new perspectives on the treatment of cancer and other related diseases. |
| format | Article |
| id | doaj-art-ca6b80af12ac4baba85d8298fac8e3ac |
| institution | Kabale University |
| issn | 2050-7771 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj-art-ca6b80af12ac4baba85d8298fac8e3ac2025-01-26T12:45:41ZengBMCBiomarker Research2050-77712025-01-0113111910.1186/s40364-025-00731-zNeutrophil extracellular traps in tumor metabolism and microenvironmentZhanrui Liu0Yuanyao Dou1Conghua Lu2Rui Han3Yong He4Department of Respiratory Disease, Daping Hospital, Army Medical UniversityDepartment of Respiratory Disease, Daping Hospital, Army Medical UniversityDepartment of Respiratory Disease, Daping Hospital, Army Medical UniversityDepartment of Respiratory Disease, Bishan hospital of Chongqing medical universityDepartment of Respiratory Disease, Daping Hospital, Army Medical UniversityAbstract Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array of physiological and pathological activities, including immune rheumatic diseases and damage to target organs. Recently, the connection between NETs and cancer has garnered significant attention. Within the tumor microenvironment and metabolism, NETs exhibit multifaceted roles, such as promoting the proliferation and migration of tumor cells, influencing redox balance, triggering angiogenesis, and driving metabolic reprogramming. This review offers a comprehensive analysis of the link between NETs and tumor metabolism, emphasizing areas that remain underexplored. These include the interaction of NETs with tumor mitochondria, their effect on redox states within tumors, their involvement in metabolic reprogramming, and their contribution to angiogenesis in tumors. Such insights lay a theoretical foundation for a deeper understanding of the role of NETs in cancer development. Moreover, the review also delves into potential therapeutic strategies that target NETs and suggests future research directions, offering new perspectives on the treatment of cancer and other related diseases.https://doi.org/10.1186/s40364-025-00731-zNeutrophil Extracellular trapsTumor metabolismMitochondriaRedox reactionMetabolic reprogrammingAngiogenesis |
| spellingShingle | Zhanrui Liu Yuanyao Dou Conghua Lu Rui Han Yong He Neutrophil extracellular traps in tumor metabolism and microenvironment Biomarker Research Neutrophil Extracellular traps Tumor metabolism Mitochondria Redox reaction Metabolic reprogramming Angiogenesis |
| title | Neutrophil extracellular traps in tumor metabolism and microenvironment |
| title_full | Neutrophil extracellular traps in tumor metabolism and microenvironment |
| title_fullStr | Neutrophil extracellular traps in tumor metabolism and microenvironment |
| title_full_unstemmed | Neutrophil extracellular traps in tumor metabolism and microenvironment |
| title_short | Neutrophil extracellular traps in tumor metabolism and microenvironment |
| title_sort | neutrophil extracellular traps in tumor metabolism and microenvironment |
| topic | Neutrophil Extracellular traps Tumor metabolism Mitochondria Redox reaction Metabolic reprogramming Angiogenesis |
| url | https://doi.org/10.1186/s40364-025-00731-z |
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