Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc
Purpose. This study aimed to differentiate patients with bilateral disc cupping associated with suprasellar tumor from patients with open-angle glaucoma by analyzing differences in optical coherence tomography (OCT) of the optic nerve. Methods. In this retrospective cross-sectional study, we collect...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/3564809 |
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| author | Michael Mimouni Hadas Stiebel-Kalish Irena Serov Gabriel Chodick Mohammad Zbedat Dan D. Gaton |
| author_facet | Michael Mimouni Hadas Stiebel-Kalish Irena Serov Gabriel Chodick Mohammad Zbedat Dan D. Gaton |
| author_sort | Michael Mimouni |
| collection | DOAJ |
| description | Purpose. This study aimed to differentiate patients with bilateral disc cupping associated with suprasellar tumor from patients with open-angle glaucoma by analyzing differences in optical coherence tomography (OCT) of the optic nerve. Methods. In this retrospective cross-sectional study, we collected data from the eyes of 25 patients with suprasellar craniopharyngioma or pituitary macroadenomas (group 1) and 35 patients with primary open-angle glaucoma (POAG) (group 2), seen between 2001 and 2015, all with a visual acuity of ≥20/40, for whom Stratus Time-Domain (TD) optic nerve OCT scans were available. The main outcome measures were the retinal nerve fiber layer (RNFL) thickness, disc area, cup volume, cup/disc ratio, and rim area. Results. A total of 31 patients met the inclusion criteria and were included in the study: 16 with suprasellar tumors and 15 with POAG. Both groups were similar in terms of gender and age (P>0.05). The glaucoma group had a borderline greater total RNFL thickness (74.2 μm versus 62.8 μm, P=0.07), disc area (2.70 mm2 versus 2.16 mm2, P=0.004), and cup volume (0.20 mm3 versus 0.08 mm3, P=0.02). In multivariate, glaucoma was associated with increased total RNFL thickness (OR = 1.116 per μm, P=0.008), increased disc area (OR = 2.402 per 100 μm2, P=0.002), and decreased rim area (OR = 0.272 per 100 μm2, P=0.011). Of these, the parameter with the greatest AUC was the disc area (AUC = 0.79). Using the Youden index, the optimal cut-off point identified for stratification was a disc area greater than 2.33 μm2. Conclusions. In patients with bilateral disc cupping, a decreased total RNFL thickness and smaller disc area seem to be associated with suprasellar tumors (when compared with open-angle glaucoma). These findings may aid in early diagnosis of cupping from suprasellar tumors, before compressive visual loss occurs. |
| format | Article |
| id | doaj-art-ca6996b546bb43908ae1b91a169fc067 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-ca6996b546bb43908ae1b91a169fc0672025-02-03T05:55:18ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/35648093564809Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic DiscMichael Mimouni0Hadas Stiebel-Kalish1Irena Serov2Gabriel Chodick3Mohammad Zbedat4Dan D. Gaton5Department of Ophthalmology, Rambam Health Care Campus, Haifa, IsraelDepartment of Ophthalmology, Rabin Medical Center-Beilinson Hospital, Petah Tikva, IsraelDepartment of Ophthalmology, Rabin Medical Center-Beilinson Hospital, Petah Tikva, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Ophthalmology, Rabin Medical Center-Beilinson Hospital, Petah Tikva, IsraelPurpose. This study aimed to differentiate patients with bilateral disc cupping associated with suprasellar tumor from patients with open-angle glaucoma by analyzing differences in optical coherence tomography (OCT) of the optic nerve. Methods. In this retrospective cross-sectional study, we collected data from the eyes of 25 patients with suprasellar craniopharyngioma or pituitary macroadenomas (group 1) and 35 patients with primary open-angle glaucoma (POAG) (group 2), seen between 2001 and 2015, all with a visual acuity of ≥20/40, for whom Stratus Time-Domain (TD) optic nerve OCT scans were available. The main outcome measures were the retinal nerve fiber layer (RNFL) thickness, disc area, cup volume, cup/disc ratio, and rim area. Results. A total of 31 patients met the inclusion criteria and were included in the study: 16 with suprasellar tumors and 15 with POAG. Both groups were similar in terms of gender and age (P>0.05). The glaucoma group had a borderline greater total RNFL thickness (74.2 μm versus 62.8 μm, P=0.07), disc area (2.70 mm2 versus 2.16 mm2, P=0.004), and cup volume (0.20 mm3 versus 0.08 mm3, P=0.02). In multivariate, glaucoma was associated with increased total RNFL thickness (OR = 1.116 per μm, P=0.008), increased disc area (OR = 2.402 per 100 μm2, P=0.002), and decreased rim area (OR = 0.272 per 100 μm2, P=0.011). Of these, the parameter with the greatest AUC was the disc area (AUC = 0.79). Using the Youden index, the optimal cut-off point identified for stratification was a disc area greater than 2.33 μm2. Conclusions. In patients with bilateral disc cupping, a decreased total RNFL thickness and smaller disc area seem to be associated with suprasellar tumors (when compared with open-angle glaucoma). These findings may aid in early diagnosis of cupping from suprasellar tumors, before compressive visual loss occurs.http://dx.doi.org/10.1155/2019/3564809 |
| spellingShingle | Michael Mimouni Hadas Stiebel-Kalish Irena Serov Gabriel Chodick Mohammad Zbedat Dan D. Gaton Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc Journal of Ophthalmology |
| title | Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc |
| title_full | Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc |
| title_fullStr | Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc |
| title_full_unstemmed | Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc |
| title_short | Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc |
| title_sort | optical coherence tomography may help distinguish glaucoma from suprasellar tumor associated optic disc |
| url | http://dx.doi.org/10.1155/2019/3564809 |
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