Multiple DNA damages induced by water radiolysis demonstrated using a dynamic Monte Carlo code
Abstract Multiple DNA damage resulting from different nearby ionizations of water molecules is an important process of the initial step of radiobiological effects. Several important characteristics of the damaged DNA site such as the critical size and types of chemical lesions are not well-known. We...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-03-01
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| Series: | Communications Chemistry |
| Online Access: | https://doi.org/10.1038/s42004-025-01453-x |
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| author | Takeshi Kai Tomohiro Toigawa Yusuke Matsuya Yuho Hirata Hidetsugu Tsuchida Yuma Ito Akinari Yokoya |
| author_facet | Takeshi Kai Tomohiro Toigawa Yusuke Matsuya Yuho Hirata Hidetsugu Tsuchida Yuma Ito Akinari Yokoya |
| author_sort | Takeshi Kai |
| collection | DOAJ |
| description | Abstract Multiple DNA damage resulting from different nearby ionizations of water molecules is an important process of the initial step of radiobiological effects. Several important characteristics of the damaged DNA site such as the critical size and types of chemical lesions are not well-known. We investigated this long-term issue by developing a dynamic Monte Carlo code for the chemical process. The reaction probabilities and the spatial distribution of lesions were theoretically solved as a function of the spur radius and distance between DNA and the initial ionisation position. From our previous reported results, we suggest that a hydroxyl radical and a hydrated electron from a single spur can concomitantly react within a 10 base pairs DNA to induce a multiple DNA damage site comprising a DNA single-strand break and reductive nucleobase damage; however, the reaction probability is 0.4% or less. Once this combination arises, it may result in a DNA double-strand break (DSB). DSBs are difficult to repair, which may lead to cell death or misrepair, and could lead to point mutations in the genome. |
| format | Article |
| id | doaj-art-ca66a4e9c89a4fdba49e77aee7bd9fdf |
| institution | DOAJ |
| issn | 2399-3669 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Chemistry |
| spelling | doaj-art-ca66a4e9c89a4fdba49e77aee7bd9fdf2025-08-20T03:05:56ZengNature PortfolioCommunications Chemistry2399-36692025-03-01811910.1038/s42004-025-01453-xMultiple DNA damages induced by water radiolysis demonstrated using a dynamic Monte Carlo codeTakeshi Kai0Tomohiro Toigawa1Yusuke Matsuya2Yuho Hirata3Hidetsugu Tsuchida4Yuma Ito5Akinari Yokoya6Nuclear Science and Engineering Center, Japan Atomic Energy AgencyNuclear Science and Engineering Center, Japan Atomic Energy AgencyNuclear Science and Engineering Center, Japan Atomic Energy AgencyNuclear Science and Engineering Center, Japan Atomic Energy AgencyDepartment of Nuclear Engineering, Kyoto UniversityCollege School of Science and Engineering, Ibaraki UniversityCollege School of Science and Engineering, Ibaraki UniversityAbstract Multiple DNA damage resulting from different nearby ionizations of water molecules is an important process of the initial step of radiobiological effects. Several important characteristics of the damaged DNA site such as the critical size and types of chemical lesions are not well-known. We investigated this long-term issue by developing a dynamic Monte Carlo code for the chemical process. The reaction probabilities and the spatial distribution of lesions were theoretically solved as a function of the spur radius and distance between DNA and the initial ionisation position. From our previous reported results, we suggest that a hydroxyl radical and a hydrated electron from a single spur can concomitantly react within a 10 base pairs DNA to induce a multiple DNA damage site comprising a DNA single-strand break and reductive nucleobase damage; however, the reaction probability is 0.4% or less. Once this combination arises, it may result in a DNA double-strand break (DSB). DSBs are difficult to repair, which may lead to cell death or misrepair, and could lead to point mutations in the genome.https://doi.org/10.1038/s42004-025-01453-x |
| spellingShingle | Takeshi Kai Tomohiro Toigawa Yusuke Matsuya Yuho Hirata Hidetsugu Tsuchida Yuma Ito Akinari Yokoya Multiple DNA damages induced by water radiolysis demonstrated using a dynamic Monte Carlo code Communications Chemistry |
| title | Multiple DNA damages induced by water radiolysis demonstrated using a dynamic Monte Carlo code |
| title_full | Multiple DNA damages induced by water radiolysis demonstrated using a dynamic Monte Carlo code |
| title_fullStr | Multiple DNA damages induced by water radiolysis demonstrated using a dynamic Monte Carlo code |
| title_full_unstemmed | Multiple DNA damages induced by water radiolysis demonstrated using a dynamic Monte Carlo code |
| title_short | Multiple DNA damages induced by water radiolysis demonstrated using a dynamic Monte Carlo code |
| title_sort | multiple dna damages induced by water radiolysis demonstrated using a dynamic monte carlo code |
| url | https://doi.org/10.1038/s42004-025-01453-x |
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