Current Perspective About the Effect of a Ketogenic Diet on Oxidative Stress – a Review
Oxidative stress (OS) plays a pivotal role in the development of many diseases. Therefore, many efforts have been undertaken to minimize the consequences of OS or improve antioxidant defence systems. One solution expected to improve redox homeostasis is the ketogenic diet (KD). KD is a low-carbohydr...
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| Format: | Article |
| Language: | English |
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Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences
2024-03-01
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| Series: | Polish Journal of Food and Nutrition Sciences |
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| Online Access: | http://journal.pan.olsztyn.pl/Current-Perspective-About-the-Effect-of-a-Ketogenic-Diet-on-Oxidative-Stress-a-Review,185366,0,2.html |
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| author | Natalia Drabińska |
| author_facet | Natalia Drabińska |
| author_sort | Natalia Drabińska |
| collection | DOAJ |
| description | Oxidative stress (OS) plays a pivotal role in the development of many diseases. Therefore, many efforts have been undertaken to minimize the consequences of OS or improve antioxidant defence systems. One solution expected to improve redox homeostasis is the ketogenic diet (KD). KD is a low-carbohydrate, high-fat diet leading to a ketosis state. The shift in metabolism occurring in ketosis can affect the reactive oxygen species (ROS)-producing pathways and influence the expression of enzymes involved in redox homeostasis. Therefore, this review summarizes and discusses existing knowledge about KD and ROS homeostasis. The available tools for evaluating OS status are presented, listing their potential and drawbacks. An important aspect is the summary of the current knowledge about the effect of KD on OS conducted in vitro, in vivo, and in clinical trials. Finally, the review addresses future studies needed to understand the connection between KD and OS. |
| format | Article |
| id | doaj-art-ca5d51d72ea049478bb4c062096b4a69 |
| institution | Kabale University |
| issn | 2083-6007 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences |
| record_format | Article |
| series | Polish Journal of Food and Nutrition Sciences |
| spelling | doaj-art-ca5d51d72ea049478bb4c062096b4a692025-02-02T23:57:21ZengInstitute of Animal Reproduction and Food Research of the Polish Academy of SciencesPolish Journal of Food and Nutrition Sciences2083-60072024-03-017419210510.31883/pjfns/185366185366Current Perspective About the Effect of a Ketogenic Diet on Oxidative Stress – a ReviewNatalia Drabińska0https://orcid.org/0000-0001-5324-5982Food Volatilomics and Sensomics Group Department of Food Technology of Plant Origin Faculty of Food Science and Nutrition, Poznan University of Life Sciences, PolandOxidative stress (OS) plays a pivotal role in the development of many diseases. Therefore, many efforts have been undertaken to minimize the consequences of OS or improve antioxidant defence systems. One solution expected to improve redox homeostasis is the ketogenic diet (KD). KD is a low-carbohydrate, high-fat diet leading to a ketosis state. The shift in metabolism occurring in ketosis can affect the reactive oxygen species (ROS)-producing pathways and influence the expression of enzymes involved in redox homeostasis. Therefore, this review summarizes and discusses existing knowledge about KD and ROS homeostasis. The available tools for evaluating OS status are presented, listing their potential and drawbacks. An important aspect is the summary of the current knowledge about the effect of KD on OS conducted in vitro, in vivo, and in clinical trials. Finally, the review addresses future studies needed to understand the connection between KD and OS.http://journal.pan.olsztyn.pl/Current-Perspective-About-the-Effect-of-a-Ketogenic-Diet-on-Oxidative-Stress-a-Review,185366,0,2.htmlketogenic dietoxidative stressantioxidantoxidationlipids |
| spellingShingle | Natalia Drabińska Current Perspective About the Effect of a Ketogenic Diet on Oxidative Stress – a Review Polish Journal of Food and Nutrition Sciences ketogenic diet oxidative stress antioxidant oxidation lipids |
| title | Current Perspective About the Effect of a Ketogenic Diet on Oxidative Stress – a Review |
| title_full | Current Perspective About the Effect of a Ketogenic Diet on Oxidative Stress – a Review |
| title_fullStr | Current Perspective About the Effect of a Ketogenic Diet on Oxidative Stress – a Review |
| title_full_unstemmed | Current Perspective About the Effect of a Ketogenic Diet on Oxidative Stress – a Review |
| title_short | Current Perspective About the Effect of a Ketogenic Diet on Oxidative Stress – a Review |
| title_sort | current perspective about the effect of a ketogenic diet on oxidative stress a review |
| topic | ketogenic diet oxidative stress antioxidant oxidation lipids |
| url | http://journal.pan.olsztyn.pl/Current-Perspective-About-the-Effect-of-a-Ketogenic-Diet-on-Oxidative-Stress-a-Review,185366,0,2.html |
| work_keys_str_mv | AT nataliadrabinska currentperspectiveabouttheeffectofaketogenicdietonoxidativestressareview |