Activation of osteoblast ferroptosis by risperidone accelerates bone loss in mice models of schizophrenia

Activation of osteoblast ferroptosis by risperidone accelerates bone loss in mice models of schizophrenia

Abstract Background Ferroptosis is an iron-dependent regulatory cell death, which plays an essential role in bone loss. This study investigated whether the mechanism of risperidone (RIS)-induced bone loss is related to ferroptosis. Methods The schizophrenia mice were induced by administering MK-801....

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Bibliographic Details
Main Authors: Hongyan Fan, Zaihong Yang, Lan Pang, Peifan Li, Changrong Duan, Guangyuan Xia, Lei Zheng
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Risperidone
Bone loss
Ferroptosis
Osteogenic differentiation
Online Access:https://doi.org/10.1186/s13018-025-05520-w
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