Upregulation of VEGFA through the adenosine A2A receptor is a crucial pathway for inhibiting pericyte apoptosis in chronic cerebral hypoperfusion
Abstract Chronic cerebral hypoperfusion (CCH) is a key factor in vascular cognitive impairment. Pericyte loss and subsequent blood-brain barrier disruption play pivotal roles in the pathogenesis of CCH-induced white matter lesions (CCH-WMLs). Previous work suggested that the adenosine A2A receptor (...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-08407-2 |
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