The Migraine-Ischemic Stroke Relation in Young Adults
In spite of the strong epidemiologic evidence linking migraine and ischemic stroke in young adults, the mechanisms explaining this association remain poorly understood. The observation that stroke occurs more frequently during the interictal phase of migraine prompts to speculation that an indirect...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.4061/2011/304921 |
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| _version_ | 1832568458893590528 |
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| author | Alessandro Pezzini Elisabetta Del Zotto Alessia Giossi Irene Volonghi Paolo Costa Giorgio Dalla Volta Alessandro Padovani |
| author_facet | Alessandro Pezzini Elisabetta Del Zotto Alessia Giossi Irene Volonghi Paolo Costa Giorgio Dalla Volta Alessandro Padovani |
| author_sort | Alessandro Pezzini |
| collection | DOAJ |
| description | In spite of the strong epidemiologic evidence linking migraine and ischemic stroke in young adults, the mechanisms explaining this association remain poorly understood. The observation that stroke occurs more frequently during the interictal phase of migraine prompts to speculation that an indirect relation between the two diseases might exist. In this regard, four major issues might be considered which may be summarized as follows: (1) the migraine-ischemic stroke relation is influenced by specific risk factors such as patent foramen ovale or endothelial dysfunction and more frequent in particular conditions like spontaneous cervical artery dissection; (2) migraine is associated with an increased prevalence of cardiovascular risk factors; (3) the link is caused by migraine-specific drugs; (4) migraine and ischemic vascular events are linked via a genetic component. In the present paper, we will review epidemiological studies, discuss potential mechanisms of migraine-induced stroke and comorbid ischemic stroke, and pose new research questions. |
| format | Article |
| id | doaj-art-ca3ed4b3d411455da3c38e8eca9a2d72 |
| institution | Kabale University |
| issn | 2042-0056 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-ca3ed4b3d411455da3c38e8eca9a2d722025-02-03T00:59:01ZengWileyStroke Research and Treatment2042-00562011-01-01201110.4061/2011/304921304921The Migraine-Ischemic Stroke Relation in Young AdultsAlessandro Pezzini0Elisabetta Del Zotto1Alessia Giossi2Irene Volonghi3Paolo Costa4Giorgio Dalla Volta5Alessandro Padovani6Dipartimento di Scienze Mediche e Chirurgiche, Clinica Neurologica, Università degli Studi di Brescia, Piazzale Spedali Civili, 1, 25100 Brescia, ItalyDipartimento di Scienze Biomediche e Biotecnologie, Università degli Studi di Brescia, 25100 Brescia, ItalyDipartimento di Scienze Mediche e Chirurgiche, Clinica Neurologica, Università degli Studi di Brescia, Piazzale Spedali Civili, 1, 25100 Brescia, ItalyDipartimento di Scienze Mediche e Chirurgiche, Clinica Neurologica, Università degli Studi di Brescia, Piazzale Spedali Civili, 1, 25100 Brescia, ItalyDipartimento di Scienze Mediche e Chirurgiche, Clinica Neurologica, Università degli Studi di Brescia, Piazzale Spedali Civili, 1, 25100 Brescia, ItalyUnità di Neurologia, Istituto Clinico Città di Brescia, 25123 Brescia, ItalyDipartimento di Scienze Mediche e Chirurgiche, Clinica Neurologica, Università degli Studi di Brescia, Piazzale Spedali Civili, 1, 25100 Brescia, ItalyIn spite of the strong epidemiologic evidence linking migraine and ischemic stroke in young adults, the mechanisms explaining this association remain poorly understood. The observation that stroke occurs more frequently during the interictal phase of migraine prompts to speculation that an indirect relation between the two diseases might exist. In this regard, four major issues might be considered which may be summarized as follows: (1) the migraine-ischemic stroke relation is influenced by specific risk factors such as patent foramen ovale or endothelial dysfunction and more frequent in particular conditions like spontaneous cervical artery dissection; (2) migraine is associated with an increased prevalence of cardiovascular risk factors; (3) the link is caused by migraine-specific drugs; (4) migraine and ischemic vascular events are linked via a genetic component. In the present paper, we will review epidemiological studies, discuss potential mechanisms of migraine-induced stroke and comorbid ischemic stroke, and pose new research questions.http://dx.doi.org/10.4061/2011/304921 |
| spellingShingle | Alessandro Pezzini Elisabetta Del Zotto Alessia Giossi Irene Volonghi Paolo Costa Giorgio Dalla Volta Alessandro Padovani The Migraine-Ischemic Stroke Relation in Young Adults Stroke Research and Treatment |
| title | The Migraine-Ischemic Stroke Relation in Young Adults |
| title_full | The Migraine-Ischemic Stroke Relation in Young Adults |
| title_fullStr | The Migraine-Ischemic Stroke Relation in Young Adults |
| title_full_unstemmed | The Migraine-Ischemic Stroke Relation in Young Adults |
| title_short | The Migraine-Ischemic Stroke Relation in Young Adults |
| title_sort | migraine ischemic stroke relation in young adults |
| url | http://dx.doi.org/10.4061/2011/304921 |
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