Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is prevalent in 20–25% of the general population and is associated with metabolic risk factors such as obesity, diabetes mellitus, and dyslipidemia. Histologically, NAFLD ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrh...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/343828 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564636152496128 |
|---|---|
| author | Elena Buzzetti Rosa Lombardi Laura De Luca Emmanuel A. Tsochatzis |
| author_facet | Elena Buzzetti Rosa Lombardi Laura De Luca Emmanuel A. Tsochatzis |
| author_sort | Elena Buzzetti |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is prevalent in 20–25% of the general population and is associated with metabolic risk factors such as obesity, diabetes mellitus, and dyslipidemia. Histologically, NAFLD ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. As NASH develops in only 10–15% of patients with NAFLD, it is not practical to biopsy all patients who present with NAFLD. Noninvasive fibrosis tests have been extensively developed recently and offer alternatives for staging fibrosis. Despite their increasing use, such tests cannot adequately differentiate simple steatosis from NASH. At present, such tests can be used as first line tests to rule out patients without advanced fibrosis and thus prevent unnecessary secondary care referrals in a significant number of patients. In this review we present the evidence for the use of noninvasive fibrosis tests in patients with NAFLD. |
| format | Article |
| id | doaj-art-ca38200c86bc46e5b6fb669890d03d7f |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ca38200c86bc46e5b6fb669890d03d7f2025-02-03T01:10:39ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/343828343828Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver DiseaseElena Buzzetti0Rosa Lombardi1Laura De Luca2Emmanuel A. Tsochatzis3UCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London NW3 2QG, UKUCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London NW3 2QG, UKUCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London NW3 2QG, UKUCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London NW3 2QG, UKNonalcoholic fatty liver disease (NAFLD) is prevalent in 20–25% of the general population and is associated with metabolic risk factors such as obesity, diabetes mellitus, and dyslipidemia. Histologically, NAFLD ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. As NASH develops in only 10–15% of patients with NAFLD, it is not practical to biopsy all patients who present with NAFLD. Noninvasive fibrosis tests have been extensively developed recently and offer alternatives for staging fibrosis. Despite their increasing use, such tests cannot adequately differentiate simple steatosis from NASH. At present, such tests can be used as first line tests to rule out patients without advanced fibrosis and thus prevent unnecessary secondary care referrals in a significant number of patients. In this review we present the evidence for the use of noninvasive fibrosis tests in patients with NAFLD.http://dx.doi.org/10.1155/2015/343828 |
| spellingShingle | Elena Buzzetti Rosa Lombardi Laura De Luca Emmanuel A. Tsochatzis Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease International Journal of Endocrinology |
| title | Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease |
| title_full | Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease |
| title_fullStr | Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease |
| title_short | Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease |
| title_sort | noninvasive assessment of fibrosis in patients with nonalcoholic fatty liver disease |
| url | http://dx.doi.org/10.1155/2015/343828 |
| work_keys_str_mv | AT elenabuzzetti noninvasiveassessmentoffibrosisinpatientswithnonalcoholicfattyliverdisease AT rosalombardi noninvasiveassessmentoffibrosisinpatientswithnonalcoholicfattyliverdisease AT lauradeluca noninvasiveassessmentoffibrosisinpatientswithnonalcoholicfattyliverdisease AT emmanuelatsochatzis noninvasiveassessmentoffibrosisinpatientswithnonalcoholicfattyliverdisease |