Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis
Objective. The mechanism of Panax notoginseng in treating myocardial fibrosis (MF) was investigated using network pharmacology. Methods. Effective ingredients and potential targets of Panax notoginseng were screened in relevant databases to construct a compound-target network. Targets of MF were the...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2022/8895950 |
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| _version_ | 1832563867494907904 |
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| author | Jingxue Han Jingyi Hou Yu Liu Peng Liu Tingting Zhao Xinwei Wang |
| author_facet | Jingxue Han Jingyi Hou Yu Liu Peng Liu Tingting Zhao Xinwei Wang |
| author_sort | Jingxue Han |
| collection | DOAJ |
| description | Objective. The mechanism of Panax notoginseng in treating myocardial fibrosis (MF) was investigated using network pharmacology. Methods. Effective ingredients and potential targets of Panax notoginseng were screened in relevant databases to construct a compound-target network. Targets of MF were then screened to select common targets and construct a protein-protein interaction network. This was followed by Gene Ontology and pathway enrichment analyses. Molecular docking then verified the results of network analysis. Results. A total of 14 effective ingredients and 119 potential targets for MF were predicted. Quercetin, beta-sitosterol, and gossypetin were speculated to be the main active ingredients. The mechanism of action may be related to AGE-RAGE, proteoglycans, and IL-17 signaling pathways. Five key targets (IL6, ALB, AKT1, TNF, and VEGFA) may be involved in the treatment of MF using Panax notoginseng. Conclusions. This study embodies the complex network relationship of multicomponents, multitargets, and multipathways of Panax notoginseng in treating MF and provides a novel method for further research on this herb’s mechanism. |
| format | Article |
| id | doaj-art-ca36bba103434eae9a4a53b55b2662b6 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ca36bba103434eae9a4a53b55b2662b62025-02-03T01:12:22ZengWileyJournal of Diabetes Research2314-67532022-01-01202210.1155/2022/8895950Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial FibrosisJingxue Han0Jingyi Hou1Yu Liu2Peng Liu3Tingting Zhao4Xinwei Wang5Beijing Key Lab for Immune-Mediated Inflammatory DiseasesSchool of Chinese Materia MedicaBeijing Key Lab for Immune-Mediated Inflammatory DiseasesShunyi HospitalBeijing Key Lab for Immune-Mediated Inflammatory DiseasesHeilongjiang Academy of Chinese Medical SciencesObjective. The mechanism of Panax notoginseng in treating myocardial fibrosis (MF) was investigated using network pharmacology. Methods. Effective ingredients and potential targets of Panax notoginseng were screened in relevant databases to construct a compound-target network. Targets of MF were then screened to select common targets and construct a protein-protein interaction network. This was followed by Gene Ontology and pathway enrichment analyses. Molecular docking then verified the results of network analysis. Results. A total of 14 effective ingredients and 119 potential targets for MF were predicted. Quercetin, beta-sitosterol, and gossypetin were speculated to be the main active ingredients. The mechanism of action may be related to AGE-RAGE, proteoglycans, and IL-17 signaling pathways. Five key targets (IL6, ALB, AKT1, TNF, and VEGFA) may be involved in the treatment of MF using Panax notoginseng. Conclusions. This study embodies the complex network relationship of multicomponents, multitargets, and multipathways of Panax notoginseng in treating MF and provides a novel method for further research on this herb’s mechanism.http://dx.doi.org/10.1155/2022/8895950 |
| spellingShingle | Jingxue Han Jingyi Hou Yu Liu Peng Liu Tingting Zhao Xinwei Wang Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis Journal of Diabetes Research |
| title | Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis |
| title_full | Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis |
| title_fullStr | Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis |
| title_full_unstemmed | Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis |
| title_short | Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis |
| title_sort | using network pharmacology to explore the mechanism of panax notoginseng in the treatment of myocardial fibrosis |
| url | http://dx.doi.org/10.1155/2022/8895950 |
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