Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and Bioavailability
Resins are complex mixtures of natural constituents containing non-volatile and volatile terpenes, in combination with gums and polyphenols, used since ancient times for their medicinal properties. Current research has evidenced their therapeutic value with a plethora of activities. The main limits...
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2025-01-01
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| Series: | Pharmaceutics |
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| author | Eleonora Truzzi Giulia Vanti Lucia Grifoni Eleonora Maretti Eliana Leo Anna Rita Bilia |
| author_facet | Eleonora Truzzi Giulia Vanti Lucia Grifoni Eleonora Maretti Eliana Leo Anna Rita Bilia |
| author_sort | Eleonora Truzzi |
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| description | Resins are complex mixtures of natural constituents containing non-volatile and volatile terpenes, in combination with gums and polyphenols, used since ancient times for their medicinal properties. Current research has evidenced their therapeutic value with a plethora of activities. The main limits of resins and their constituents for their clinical use are low water solubility, poor stability and bioavailability. Therefore, nanovectors including vesicles, solid lipid nanoparticles, micelles, nanoemulsions, microemulsions and mesoporic nanoparticles have been investigated to optimize the biopharmaceutical properties after topical or oral administration of resins or fractions from them, including essential oils or single constituents. In this review, we report the results evidencing that developed nanovectors were able to entrap high amounts of resins or their components, modify the release properties, enhance their cellular uptake and penetration across biological barriers and optimize the biopharmaceutical properties. In addition, the resins or their fractions as enhancer penetration molecules can optimize the architecture and properties of nanovectors in their capacity to circumvent biological barriers. Although no clinical studies have been reported until now, nanovectors represent a huge platform for upgrading therapies and emerging new treatments of resins such as wound healing therapy. |
| format | Article |
| id | doaj-art-ca33096c85ef4426a73c0951a5cd4d55 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj-art-ca33096c85ef4426a73c0951a5cd4d552025-01-24T13:45:44ZengMDPI AGPharmaceutics1999-49232025-01-011715310.3390/pharmaceutics17010053Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and BioavailabilityEleonora Truzzi0Giulia Vanti1Lucia Grifoni2Eleonora Maretti3Eliana Leo4Anna Rita Bilia5Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, ItalyDepartment of Chemistry “Ugo Schiff” (DICUS), University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, ItalyDepartment of Chemistry “Ugo Schiff” (DICUS), University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, ItalyDepartment of Chemistry “Ugo Schiff” (DICUS), University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, ItalyResins are complex mixtures of natural constituents containing non-volatile and volatile terpenes, in combination with gums and polyphenols, used since ancient times for their medicinal properties. Current research has evidenced their therapeutic value with a plethora of activities. The main limits of resins and their constituents for their clinical use are low water solubility, poor stability and bioavailability. Therefore, nanovectors including vesicles, solid lipid nanoparticles, micelles, nanoemulsions, microemulsions and mesoporic nanoparticles have been investigated to optimize the biopharmaceutical properties after topical or oral administration of resins or fractions from them, including essential oils or single constituents. In this review, we report the results evidencing that developed nanovectors were able to entrap high amounts of resins or their components, modify the release properties, enhance their cellular uptake and penetration across biological barriers and optimize the biopharmaceutical properties. In addition, the resins or their fractions as enhancer penetration molecules can optimize the architecture and properties of nanovectors in their capacity to circumvent biological barriers. Although no clinical studies have been reported until now, nanovectors represent a huge platform for upgrading therapies and emerging new treatments of resins such as wound healing therapy.https://www.mdpi.com/1999-4923/17/1/53plant resins and their essential oils<i>Boswellia</i> and <i>Commiphora</i><i>Pistacia</i><i>Pinus</i> and <i>Picea</i><i>Ferula</i><i>Dracaena</i> |
| spellingShingle | Eleonora Truzzi Giulia Vanti Lucia Grifoni Eleonora Maretti Eliana Leo Anna Rita Bilia Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and Bioavailability Pharmaceutics plant resins and their essential oils <i>Boswellia</i> and <i>Commiphora</i> <i>Pistacia</i> <i>Pinus</i> and <i>Picea</i> <i>Ferula</i> <i>Dracaena</i> |
| title | Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and Bioavailability |
| title_full | Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and Bioavailability |
| title_fullStr | Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and Bioavailability |
| title_full_unstemmed | Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and Bioavailability |
| title_short | Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and Bioavailability |
| title_sort | plant resin delivery by nanovectors as an emerging approach to boost solubility permeability and bioavailability |
| topic | plant resins and their essential oils <i>Boswellia</i> and <i>Commiphora</i> <i>Pistacia</i> <i>Pinus</i> and <i>Picea</i> <i>Ferula</i> <i>Dracaena</i> |
| url | https://www.mdpi.com/1999-4923/17/1/53 |
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