Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in Rat
Aim was evaluation of the effects of cosupplementation of, vitamins E and C, in preventing renal scarring in acute pyelonephritis. Animals and Treatments. Sixty rats were used, bacteria was injected through kidney. The rats were arranged randomly in 3 groups of 20 rats each. Rats in groups 1 and 2 w...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2011/489496 |
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| author | Fatemeh Emamghorashi Seyed Mohamad Owji Mohammad Motamedifar |
| author_facet | Fatemeh Emamghorashi Seyed Mohamad Owji Mohammad Motamedifar |
| author_sort | Fatemeh Emamghorashi |
| collection | DOAJ |
| description | Aim was evaluation of the effects of cosupplementation of, vitamins E and C, in preventing renal scarring in acute pyelonephritis. Animals and Treatments. Sixty rats were used, bacteria was injected through kidney. The rats were arranged randomly in 3 groups of 20 rats each. Rats in groups 1 and 2 were given once-daily intraperitoneal injections of gentamicin for ten consecutive days, beginning on the third day after inoculation. In group 2, vitamins E and C cotreatment and in group 3, vitamins E and C cotreatment without gentamicin injection were started. Three rats in each group were killed 24 hours after the inoculation (for infection and inflammation document) and forty-eight hours after the antibiotic injection (for efficacy of treatment). After eight weeks, the rest of rats were killed, and kidneys evaluated for percent of scaring. Result. There was also significant difference of degree of scar formation (1.4 and 3.4% versus 8.6%, 𝑃=.001). The group which received gentamicin only had moderate to severe scaring, but the two groups which received vitamin C and vitamin E showed no or mild renal scaring. Conclusion. The study showed that administration of antioxidants can protect scaring due to pyelonephritis with or without antibiotic administration. |
| format | Article |
| id | doaj-art-ca30e75e64554d20a60e2be9a9363c98 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-ca30e75e64554d20a60e2be9a9363c982025-02-03T05:43:44ZengWileyAdvances in Urology1687-63691687-63772011-01-01201110.1155/2011/489496489496Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in RatFatemeh Emamghorashi0Seyed Mohamad Owji1Mohammad Motamedifar2Department of Pediatrics, Shiraz Nephrology Urology Research Center, Jahrom University of Medical Sciences Jahrom, IranDepartment of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences Shiraz, IranDepartment of Bacteriology and Virology, Medical School, Shiraz HIV/Aids Research Center (SHARC), Shiraz University of Medical Sciences, Shiraz, IranAim was evaluation of the effects of cosupplementation of, vitamins E and C, in preventing renal scarring in acute pyelonephritis. Animals and Treatments. Sixty rats were used, bacteria was injected through kidney. The rats were arranged randomly in 3 groups of 20 rats each. Rats in groups 1 and 2 were given once-daily intraperitoneal injections of gentamicin for ten consecutive days, beginning on the third day after inoculation. In group 2, vitamins E and C cotreatment and in group 3, vitamins E and C cotreatment without gentamicin injection were started. Three rats in each group were killed 24 hours after the inoculation (for infection and inflammation document) and forty-eight hours after the antibiotic injection (for efficacy of treatment). After eight weeks, the rest of rats were killed, and kidneys evaluated for percent of scaring. Result. There was also significant difference of degree of scar formation (1.4 and 3.4% versus 8.6%, 𝑃=.001). The group which received gentamicin only had moderate to severe scaring, but the two groups which received vitamin C and vitamin E showed no or mild renal scaring. Conclusion. The study showed that administration of antioxidants can protect scaring due to pyelonephritis with or without antibiotic administration.http://dx.doi.org/10.1155/2011/489496 |
| spellingShingle | Fatemeh Emamghorashi Seyed Mohamad Owji Mohammad Motamedifar Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in Rat Advances in Urology |
| title | Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in Rat |
| title_full | Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in Rat |
| title_fullStr | Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in Rat |
| title_full_unstemmed | Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in Rat |
| title_short | Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in Rat |
| title_sort | evaluation of effectiveness of vitamins c and e on prevention of renal scar due to pyelonephritis in rat |
| url | http://dx.doi.org/10.1155/2011/489496 |
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