The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis
Hepatitis B virus-related acute liver failure (HBV-ALF) is a common type of liver failure, associated with high short-term mortality and morbidity rates. However, the immune landscape of HBV-ALF and its correlation with cell death are currently unknown. Based on 3 Gene Expression Omnibus data sets,...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/6764379 |
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| author | Jiao Gong Yaqiong Chen Jing Cao Yang Wang Jiahao Chen Danyang Li Liuping Sha Xinhua Li Yutian Chong Bo Hu |
| author_facet | Jiao Gong Yaqiong Chen Jing Cao Yang Wang Jiahao Chen Danyang Li Liuping Sha Xinhua Li Yutian Chong Bo Hu |
| author_sort | Jiao Gong |
| collection | DOAJ |
| description | Hepatitis B virus-related acute liver failure (HBV-ALF) is a common type of liver failure, associated with high short-term mortality and morbidity rates. However, the immune landscape of HBV-ALF and its correlation with cell death are currently unknown. Based on 3 Gene Expression Omnibus data sets, infiltrated immune cells were quantified by single-sample gene set enrichment analysis method. The expression levels of immune genes and the abundance of immune cells in liver failure were compared with those in normal liver. The enrichment scores of cell death gene sets from Kyoto Encyclopedia of Genes and Genomes (KEGG) were calculated by gene set variation analysis method, and a protein-protein interaction (PPI) network was constructed using Cytoscape. Besides 21 differentially expressed immune genes, we identified 11 types of differentially infiltrated immune cells in HBV-ALF compared with normal liver. Enriched pathways of these immune genes mainly consisted of chemokine receptors, chemokine binding, interleukin-10 signaling, and TNFs bind their physiological receptors by Reactome pathway analysis. In addition, the enrichment scores of apoptosis and necroptosis pathway instead of autophagy and ferroptosis were increased in liver failure compared with normal liver. PPI network and gene cluster analysis of immune genes and apoptosis and necroptosis genes suggested that hub genes were mainly related to immune response and apoptosis. In summary, our study offers a conceptual framework to understand the immune landscape of HBV-ALF, which might help to improve prognosis. |
| format | Article |
| id | doaj-art-ca1f16ad7e3842fe9a7c9f8af75092ad |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-ca1f16ad7e3842fe9a7c9f8af75092ad2025-02-03T01:30:39ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/6764379The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration AnalysisJiao Gong0Yaqiong Chen1Jing Cao2Yang Wang3Jiahao Chen4Danyang Li5Liuping Sha6Xinhua Li7Yutian Chong8Bo Hu9Department of Laboratory MedicineDepartment of Laboratory MedicineDepartment of Infectious DiseasesDepartment of Laboratory MedicineDepartment of Laboratory MedicineDepartment of Infectious DiseasesDepartment of Infectious DiseasesDepartment of Infectious DiseasesDepartment of Infectious DiseasesDepartment of Laboratory MedicineHepatitis B virus-related acute liver failure (HBV-ALF) is a common type of liver failure, associated with high short-term mortality and morbidity rates. However, the immune landscape of HBV-ALF and its correlation with cell death are currently unknown. Based on 3 Gene Expression Omnibus data sets, infiltrated immune cells were quantified by single-sample gene set enrichment analysis method. The expression levels of immune genes and the abundance of immune cells in liver failure were compared with those in normal liver. The enrichment scores of cell death gene sets from Kyoto Encyclopedia of Genes and Genomes (KEGG) were calculated by gene set variation analysis method, and a protein-protein interaction (PPI) network was constructed using Cytoscape. Besides 21 differentially expressed immune genes, we identified 11 types of differentially infiltrated immune cells in HBV-ALF compared with normal liver. Enriched pathways of these immune genes mainly consisted of chemokine receptors, chemokine binding, interleukin-10 signaling, and TNFs bind their physiological receptors by Reactome pathway analysis. In addition, the enrichment scores of apoptosis and necroptosis pathway instead of autophagy and ferroptosis were increased in liver failure compared with normal liver. PPI network and gene cluster analysis of immune genes and apoptosis and necroptosis genes suggested that hub genes were mainly related to immune response and apoptosis. In summary, our study offers a conceptual framework to understand the immune landscape of HBV-ALF, which might help to improve prognosis.http://dx.doi.org/10.1155/2022/6764379 |
| spellingShingle | Jiao Gong Yaqiong Chen Jing Cao Yang Wang Jiahao Chen Danyang Li Liuping Sha Xinhua Li Yutian Chong Bo Hu The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis Journal of Immunology Research |
| title | The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis |
| title_full | The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis |
| title_fullStr | The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis |
| title_full_unstemmed | The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis |
| title_short | The Immune Landscape of Hepatitis B Virus-Related Acute Liver Failure by Integration Analysis |
| title_sort | immune landscape of hepatitis b virus related acute liver failure by integration analysis |
| url | http://dx.doi.org/10.1155/2022/6764379 |
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