Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implications
Neonatal meningitis and sepsis were diagnosed in a 32-day-old preterm-born infant. Streptococcus (S.) suis was isolated from cerebrospinal fluid and blood. Next-generation sequencing revealed that the strain was serotype 2 sequence type 1, and contained the ermB and tet(W) genes, which are responsib...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1519247/full |
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| author | Giovanna Fusco Rubina Paradiso Lorena Cardillo Maria Antonia Salvia Saveria Dodaro Veronica Del Monaco Gianfranco Scarpelli Francesca Greco Antonio Rinaldi Lorella Barca Stefania Ambrogio Antonio Limone Esterina De Carlo Giorgia Borriello |
| author_facet | Giovanna Fusco Rubina Paradiso Lorena Cardillo Maria Antonia Salvia Saveria Dodaro Veronica Del Monaco Gianfranco Scarpelli Francesca Greco Antonio Rinaldi Lorella Barca Stefania Ambrogio Antonio Limone Esterina De Carlo Giorgia Borriello |
| author_sort | Giovanna Fusco |
| collection | DOAJ |
| description | Neonatal meningitis and sepsis were diagnosed in a 32-day-old preterm-born infant. Streptococcus (S.) suis was isolated from cerebrospinal fluid and blood. Next-generation sequencing revealed that the strain was serotype 2 sequence type 1, and contained the ermB and tet(W) genes, which are responsible for resistance to macrolides and tetracycline, along with several pilus-associated genes and 20 virulence factors. High homology was observed with previously identified human and swine strains in the same area. S. suis meningitis and sepsis are mainly reported in adults, related to direct contact with pigs or contaminated pork meat consumption, while it is rarely reported in children. Herein, we describe the first case of S. suis in a newborn associated with meningitis and antimicrobial resistance. The rates of resistance to tetracyclines, lincosamides, and macrolides for this bacterium are increasing and are creating concern worldwide. Altogether, our findings highlight the importance of investigating S. suis in cases of neonatal meningitis, as well as the necessity of assessing the antimicrobial profile to obtain useful information for developing targeted therapies. |
| format | Article |
| id | doaj-art-ca1cc6a651c4407483bde4dcac5793d8 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-ca1cc6a651c4407483bde4dcac5793d82025-01-28T06:41:29ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011610.3389/fmicb.2025.15192471519247Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implicationsGiovanna Fusco0Rubina Paradiso1Lorena Cardillo2Maria Antonia Salvia3Saveria Dodaro4Veronica Del Monaco5Gianfranco Scarpelli6Francesca Greco7Antonio Rinaldi8Lorella Barca9Stefania Ambrogio10Antonio Limone11Esterina De Carlo12Giorgia Borriello13Department of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, ItalyDepartmental Unit of Genetics, Bioinformatics, and Biobank, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, ItalyDepartment of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, ItalyUnit of Neonatology and Neonatal Intensive Care, “Annunziata” Hub Hospital, Azienda Ospedaliera di Cosenza, Cosenza, ItalyUnit of Microbiology and Virology, “Annunziata” Hub Hospital, Azienda Ospedaliera di Cosenza, Cosenza, ItalyDepartment of Animal Health, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, ItalyUnit of Neonatology and Neonatal Intensive Care, “Annunziata” Hub Hospital, Azienda Ospedaliera di Cosenza, Cosenza, ItalyUnit of Microbiology and Virology, “Annunziata” Hub Hospital, Azienda Ospedaliera di Cosenza, Cosenza, ItalyDepartmental Unit of Genetics, Bioinformatics, and Biobank, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, ItalyCosenza Section, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Cosenza, ItalyCosenza Section, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Cosenza, ItalyGeneral Direction, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, ItalySanitary Direction, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, ItalyDepartmental Unit of Genetics, Bioinformatics, and Biobank, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Naples, ItalyNeonatal meningitis and sepsis were diagnosed in a 32-day-old preterm-born infant. Streptococcus (S.) suis was isolated from cerebrospinal fluid and blood. Next-generation sequencing revealed that the strain was serotype 2 sequence type 1, and contained the ermB and tet(W) genes, which are responsible for resistance to macrolides and tetracycline, along with several pilus-associated genes and 20 virulence factors. High homology was observed with previously identified human and swine strains in the same area. S. suis meningitis and sepsis are mainly reported in adults, related to direct contact with pigs or contaminated pork meat consumption, while it is rarely reported in children. Herein, we describe the first case of S. suis in a newborn associated with meningitis and antimicrobial resistance. The rates of resistance to tetracyclines, lincosamides, and macrolides for this bacterium are increasing and are creating concern worldwide. Altogether, our findings highlight the importance of investigating S. suis in cases of neonatal meningitis, as well as the necessity of assessing the antimicrobial profile to obtain useful information for developing targeted therapies.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1519247/fullStreptococcus suisneonatal meningitismolecular characterizationantimicrobial resistancevertical transmission |
| spellingShingle | Giovanna Fusco Rubina Paradiso Lorena Cardillo Maria Antonia Salvia Saveria Dodaro Veronica Del Monaco Gianfranco Scarpelli Francesca Greco Antonio Rinaldi Lorella Barca Stefania Ambrogio Antonio Limone Esterina De Carlo Giorgia Borriello Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implications Frontiers in Microbiology Streptococcus suis neonatal meningitis molecular characterization antimicrobial resistance vertical transmission |
| title | Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implications |
| title_full | Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implications |
| title_fullStr | Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implications |
| title_full_unstemmed | Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implications |
| title_short | Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implications |
| title_sort | streptococcus suis associated neonatal meningitis and sepsis characterization antimicrobial resistance and public health implications |
| topic | Streptococcus suis neonatal meningitis molecular characterization antimicrobial resistance vertical transmission |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1519247/full |
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