D-dimer as a predictor of severity and outcome in acute pancreatitis
This prospective observational study, conducted at Jubilee Mission Medical College and Research Institute, Thrissur, explored the role of D-dimer as a predictive marker for the severity and outcomes of acute pancreatitis. A total of 60 patients diagnosed through clinical, biochemical, and imaging cr...
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KIMS Foundation and Research Center
2024-10-01
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| Series: | Journal of Medical and Scientific Research |
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| Online Access: | https://jmsronline.com/archive-article/D-dimer-predictor-severity-outcome-acute-pancreatitis |
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| author | Joseph A Harikrishnan CP Oommen AN Nair A |
| author_facet | Joseph A Harikrishnan CP Oommen AN Nair A |
| author_sort | Joseph A |
| collection | DOAJ |
| description | This prospective observational study, conducted at Jubilee Mission Medical College and Research Institute, Thrissur, explored the role of D-dimer as a predictive marker for the severity and outcomes of acute pancreatitis. A total of 60 patients diagnosed through clinical, biochemical, and imaging criteria were included. The study demonstrated a significant correlation between elevated D-dimer levels and the severity of acute pancreatitis, classified according to the Atlanta criteria. Specifically, D-dimer levels ≥2528 ng/L were strongly associated with severe acute pancreatitis (SAP), while levels ≤1871 ng/L were primarily linked to mild cases. The study identified a D-dimer cutoff value of 1871 ng/L as an effective predictor of complications, with an area under the curve (AUC) of 0.870, yielding 87.5% sensitivity, 83.3% specificity, a positive predictive value of 77.78%, a negative predictive value of 90.90%, and 85% overall accuracy. In addition to severity prediction, the study examined the association between D-dimer levels and the need for supportive interventions. These findings suggest that D-dimer is a valuable biomarker for early risk stratification and could aid in guiding therapeutic decisions in the management of acute pancreatitis. The study emphasizes the importance of conducting larger, multi-center trials to validate these findings and to better understand the prognostic value of D-dimer in diverse clinical settings, potentially enhancing early diagnosis and personalized treatment strategies for patients with acute pancreatitis.
Keywords: acute pancreatitis; D-dimer; severity prediction; clinical outcomes; biomarkers; prognostic marker; coagulation |
| format | Article |
| id | doaj-art-ca0999d20ed944058bf6e23fa73d4ce4 |
| institution | Kabale University |
| issn | 2321-1326 2394-112X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | KIMS Foundation and Research Center |
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| series | Journal of Medical and Scientific Research |
| spelling | doaj-art-ca0999d20ed944058bf6e23fa73d4ce42025-01-22T09:49:47ZengKIMS Foundation and Research CenterJournal of Medical and Scientific Research2321-13262394-112X2024-10-01124125210.17727/JMSR.2024/12-52D-dimer as a predictor of severity and outcome in acute pancreatitisJoseph A0Harikrishnan CP1Oommen AN2Nair A3Department of General Surgery, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala 680005, IndiaDepartment of General Surgery, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala 680005, IndiaDepartment of General Surgery, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala 680005, IndiaDepartment of General Surgery, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala 680005, IndiaThis prospective observational study, conducted at Jubilee Mission Medical College and Research Institute, Thrissur, explored the role of D-dimer as a predictive marker for the severity and outcomes of acute pancreatitis. A total of 60 patients diagnosed through clinical, biochemical, and imaging criteria were included. The study demonstrated a significant correlation between elevated D-dimer levels and the severity of acute pancreatitis, classified according to the Atlanta criteria. Specifically, D-dimer levels ≥2528 ng/L were strongly associated with severe acute pancreatitis (SAP), while levels ≤1871 ng/L were primarily linked to mild cases. The study identified a D-dimer cutoff value of 1871 ng/L as an effective predictor of complications, with an area under the curve (AUC) of 0.870, yielding 87.5% sensitivity, 83.3% specificity, a positive predictive value of 77.78%, a negative predictive value of 90.90%, and 85% overall accuracy. In addition to severity prediction, the study examined the association between D-dimer levels and the need for supportive interventions. These findings suggest that D-dimer is a valuable biomarker for early risk stratification and could aid in guiding therapeutic decisions in the management of acute pancreatitis. The study emphasizes the importance of conducting larger, multi-center trials to validate these findings and to better understand the prognostic value of D-dimer in diverse clinical settings, potentially enhancing early diagnosis and personalized treatment strategies for patients with acute pancreatitis. Keywords: acute pancreatitis; D-dimer; severity prediction; clinical outcomes; biomarkers; prognostic marker; coagulationhttps://jmsronline.com/archive-article/D-dimer-predictor-severity-outcome-acute-pancreatitisacute pancreatitisd-dimerseverity predictionclinical outcomesbiomarkersprognostic marker |
| spellingShingle | Joseph A Harikrishnan CP Oommen AN Nair A D-dimer as a predictor of severity and outcome in acute pancreatitis Journal of Medical and Scientific Research acute pancreatitis d-dimer severity prediction clinical outcomes biomarkers prognostic marker |
| title | D-dimer as a predictor of severity and outcome in acute pancreatitis |
| title_full | D-dimer as a predictor of severity and outcome in acute pancreatitis |
| title_fullStr | D-dimer as a predictor of severity and outcome in acute pancreatitis |
| title_full_unstemmed | D-dimer as a predictor of severity and outcome in acute pancreatitis |
| title_short | D-dimer as a predictor of severity and outcome in acute pancreatitis |
| title_sort | d dimer as a predictor of severity and outcome in acute pancreatitis |
| topic | acute pancreatitis d-dimer severity prediction clinical outcomes biomarkers prognostic marker |
| url | https://jmsronline.com/archive-article/D-dimer-predictor-severity-outcome-acute-pancreatitis |
| work_keys_str_mv | AT josepha ddimerasapredictorofseverityandoutcomeinacutepancreatitis AT harikrishnancp ddimerasapredictorofseverityandoutcomeinacutepancreatitis AT oommenan ddimerasapredictorofseverityandoutcomeinacutepancreatitis AT naira ddimerasapredictorofseverityandoutcomeinacutepancreatitis |