D-dimer as a predictor of severity and outcome in acute pancreatitis
This prospective observational study, conducted at Jubilee Mission Medical College and Research Institute, Thrissur, explored the role of D-dimer as a predictive marker for the severity and outcomes of acute pancreatitis. A total of 60 patients diagnosed through clinical, biochemical, and imaging cr...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KIMS Foundation and Research Center
2024-10-01
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| Series: | Journal of Medical and Scientific Research |
| Subjects: | |
| Online Access: | https://jmsronline.com/archive-article/D-dimer-predictor-severity-outcome-acute-pancreatitis |
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| Summary: | This prospective observational study, conducted at Jubilee Mission Medical College and Research Institute, Thrissur, explored the role of D-dimer as a predictive marker for the severity and outcomes of acute pancreatitis. A total of 60 patients diagnosed through clinical, biochemical, and imaging criteria were included. The study demonstrated a significant correlation between elevated D-dimer levels and the severity of acute pancreatitis, classified according to the Atlanta criteria. Specifically, D-dimer levels ≥2528 ng/L were strongly associated with severe acute pancreatitis (SAP), while levels ≤1871 ng/L were primarily linked to mild cases. The study identified a D-dimer cutoff value of 1871 ng/L as an effective predictor of complications, with an area under the curve (AUC) of 0.870, yielding 87.5% sensitivity, 83.3% specificity, a positive predictive value of 77.78%, a negative predictive value of 90.90%, and 85% overall accuracy. In addition to severity prediction, the study examined the association between D-dimer levels and the need for supportive interventions. These findings suggest that D-dimer is a valuable biomarker for early risk stratification and could aid in guiding therapeutic decisions in the management of acute pancreatitis. The study emphasizes the importance of conducting larger, multi-center trials to validate these findings and to better understand the prognostic value of D-dimer in diverse clinical settings, potentially enhancing early diagnosis and personalized treatment strategies for patients with acute pancreatitis.
Keywords: acute pancreatitis; D-dimer; severity prediction; clinical outcomes; biomarkers; prognostic marker; coagulation |
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| ISSN: | 2321-1326 2394-112X |