Regulatory role of PPAR in colorectal cancer
Abstract Colorectal cancer (CRC) is one of the most common tumors in the digestive system, and the majority of patients are found to be in advanced stages, which is a burden to human health all over the world. Moreover, in recent years, CRC has been progressively becoming younger, with an increasing...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02313-2 |
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| _version_ | 1832572031826132992 |
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| author | Cong Wang Tingcong Lv Binghui Jin Yang Li Zhe Fan |
| author_facet | Cong Wang Tingcong Lv Binghui Jin Yang Li Zhe Fan |
| author_sort | Cong Wang |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) is one of the most common tumors in the digestive system, and the majority of patients are found to be in advanced stages, which is a burden to human health all over the world. Moreover, in recent years, CRC has been progressively becoming younger, with an increasing incidence mainly among patients <50 years old. Despite the increase in awareness of CRC and the continuous improvement of medical treatment nowadays, the challenge of CRC still needs to be conquered. By now, the pathogenesis of CRC is complex and not fully understood. With the deepening of research, it has been revealed that PPARs, as a transcription factor, are inextricably linked to CRC. This article outlines the mechanisms by which PPARs are involved in CRC development. An in-depth understanding of the pathways related to PPARs may provide new ways of developing effective therapies for CRC with PPARs as potential targets. |
| format | Article |
| id | doaj-art-ca07e00b305e4a7c9b105524bcd269e7 |
| institution | Kabale University |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-ca07e00b305e4a7c9b105524bcd269e72025-02-02T12:08:48ZengNature Publishing GroupCell Death Discovery2058-77162025-01-0111111110.1038/s41420-025-02313-2Regulatory role of PPAR in colorectal cancerCong Wang0Tingcong Lv1Binghui Jin2Yang Li3Zhe Fan4Department of General Surgery, The Third People’s Hospital of Dalian, Dalian Medical UniversityDepartment of General Surgery, The Third People’s Hospital of Dalian, Dalian Medical UniversityDepartment of General Surgery, The Third People’s Hospital of Dalian, Dalian Medical UniversityDepartment of Breast Surgery, Cancer Hospital of China Medical UniversityDepartment of General Surgery, The Third People’s Hospital of Dalian, Dalian Medical UniversityAbstract Colorectal cancer (CRC) is one of the most common tumors in the digestive system, and the majority of patients are found to be in advanced stages, which is a burden to human health all over the world. Moreover, in recent years, CRC has been progressively becoming younger, with an increasing incidence mainly among patients <50 years old. Despite the increase in awareness of CRC and the continuous improvement of medical treatment nowadays, the challenge of CRC still needs to be conquered. By now, the pathogenesis of CRC is complex and not fully understood. With the deepening of research, it has been revealed that PPARs, as a transcription factor, are inextricably linked to CRC. This article outlines the mechanisms by which PPARs are involved in CRC development. An in-depth understanding of the pathways related to PPARs may provide new ways of developing effective therapies for CRC with PPARs as potential targets.https://doi.org/10.1038/s41420-025-02313-2 |
| spellingShingle | Cong Wang Tingcong Lv Binghui Jin Yang Li Zhe Fan Regulatory role of PPAR in colorectal cancer Cell Death Discovery |
| title | Regulatory role of PPAR in colorectal cancer |
| title_full | Regulatory role of PPAR in colorectal cancer |
| title_fullStr | Regulatory role of PPAR in colorectal cancer |
| title_full_unstemmed | Regulatory role of PPAR in colorectal cancer |
| title_short | Regulatory role of PPAR in colorectal cancer |
| title_sort | regulatory role of ppar in colorectal cancer |
| url | https://doi.org/10.1038/s41420-025-02313-2 |
| work_keys_str_mv | AT congwang regulatoryroleofpparincolorectalcancer AT tingconglv regulatoryroleofpparincolorectalcancer AT binghuijin regulatoryroleofpparincolorectalcancer AT yangli regulatoryroleofpparincolorectalcancer AT zhefan regulatoryroleofpparincolorectalcancer |