The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study
Abstract Background Recent stressful life events (SLEs) are an established risk factor for a range of psychiatric disorders. Animal studies have shown evidence of gray matter (GM) reductions associated with stress, and previous work has found similar associations in humans. However longitudinal stud...
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Cambridge University Press
2025-01-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933825000021/type/journal_article |
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| author | Cheryl R.Z. See Annabel X. Tan Lucia R. Valmaggia Matthew J. Kempton |
| author_facet | Cheryl R.Z. See Annabel X. Tan Lucia R. Valmaggia Matthew J. Kempton |
| author_sort | Cheryl R.Z. See |
| collection | DOAJ |
| description | Abstract
Background
Recent stressful life events (SLEs) are an established risk factor for a range of psychiatric disorders. Animal studies have shown evidence of gray matter (GM) reductions associated with stress, and previous work has found similar associations in humans. However longitudinal studies investigating the association between stress and changes in brain structure are limited.
Methods
The current study uses longitudinal data from the UK Biobank and comprises 4,543 participants with structural neuroimaging and recent SLE data (mean age = 61.5 years). We analyzed the association between recent SLEs and changes in brain structure, determined using the longitudinal FreeSurfer pipeline, focusing on total GM volume and five a priori brain regions: the hippocampus, amygdala, anterior cingulate cortex, orbitofrontal cortex, and insula. We also examined if depression and childhood adversity moderated the relationship between SLEs and brain structure.
Results
Individuals who had experienced recent SLEs exhibited a slower rate of hippocampal decrease over time compared to individuals who did not report any SLEs. Individuals with depression exhibited smaller GM volumes when exposed to recent SLEs. There was no effect of childhood adversity on the relationship between SLEs and brain structure.
Conclusions
Our findings suggest recent SLEs are not directly associated with an accelerated decline in brain volumes in a population sample of older adults, but instead may alter brain structure via affective disorder psychopathology. Further work is needed to investigate the effects of stress in younger populations who may be more vulnerable to stress-induced changes, and may yet pinpoint brain regions linked to stress-related disorders.
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| format | Article |
| id | doaj-art-ca0509c524884098bbc4aa793259ab77 |
| institution | Kabale University |
| issn | 0924-9338 1778-3585 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj-art-ca0509c524884098bbc4aa793259ab772025-01-28T06:58:58ZengCambridge University PressEuropean Psychiatry0924-93381778-35852025-01-016810.1192/j.eurpsy.2025.2The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI studyCheryl R.Z. See0https://orcid.org/0000-0003-2135-5495Annabel X. Tan1https://orcid.org/0000-0001-8368-0301Lucia R. Valmaggia2https://orcid.org/0000-0001-6099-8464Matthew J. Kempton3https://orcid.org/0000-0003-3541-9947Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USACentre for Youth Mental Health, University of Melbourne, Parkville, VIC, Australia Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK Department of Psychiatry, KU Leuven, Leuven, BelgiumDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKAbstract Background Recent stressful life events (SLEs) are an established risk factor for a range of psychiatric disorders. Animal studies have shown evidence of gray matter (GM) reductions associated with stress, and previous work has found similar associations in humans. However longitudinal studies investigating the association between stress and changes in brain structure are limited. Methods The current study uses longitudinal data from the UK Biobank and comprises 4,543 participants with structural neuroimaging and recent SLE data (mean age = 61.5 years). We analyzed the association between recent SLEs and changes in brain structure, determined using the longitudinal FreeSurfer pipeline, focusing on total GM volume and five a priori brain regions: the hippocampus, amygdala, anterior cingulate cortex, orbitofrontal cortex, and insula. We also examined if depression and childhood adversity moderated the relationship between SLEs and brain structure. Results Individuals who had experienced recent SLEs exhibited a slower rate of hippocampal decrease over time compared to individuals who did not report any SLEs. Individuals with depression exhibited smaller GM volumes when exposed to recent SLEs. There was no effect of childhood adversity on the relationship between SLEs and brain structure. Conclusions Our findings suggest recent SLEs are not directly associated with an accelerated decline in brain volumes in a population sample of older adults, but instead may alter brain structure via affective disorder psychopathology. Further work is needed to investigate the effects of stress in younger populations who may be more vulnerable to stress-induced changes, and may yet pinpoint brain regions linked to stress-related disorders. https://www.cambridge.org/core/product/identifier/S0924933825000021/type/journal_articlegray matterlongitudinalrecent stressstructural neuroimaging |
| spellingShingle | Cheryl R.Z. See Annabel X. Tan Lucia R. Valmaggia Matthew J. Kempton The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study European Psychiatry gray matter longitudinal recent stress structural neuroimaging |
| title | The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study |
| title_full | The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study |
| title_fullStr | The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study |
| title_full_unstemmed | The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study |
| title_short | The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study |
| title_sort | association between recent stressful life events and brain structure a uk biobank longitudinal mri study |
| topic | gray matter longitudinal recent stress structural neuroimaging |
| url | https://www.cambridge.org/core/product/identifier/S0924933825000021/type/journal_article |
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