Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis
Pulmonary fibrosis is a progressive, disabling disease with mortality rates that appear to be increasing in the western population, including the USA. There are over 140 known causes of pulmonary fibrosis as well as many unknown causes. Treatment options for this disease are limited due to poor und...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/105707 |
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| author | Rupa Biswas Melisa Bunderson-Schelvan Andrij Holian |
| author_facet | Rupa Biswas Melisa Bunderson-Schelvan Andrij Holian |
| author_sort | Rupa Biswas |
| collection | DOAJ |
| description | Pulmonary fibrosis is a progressive, disabling disease with mortality rates that appear to be increasing in the western population, including the USA. There are over 140 known causes of pulmonary fibrosis as well as many unknown causes. Treatment options for this disease are limited due to poor understanding of the molecular mechanisms of the disease progression. However, recent progress in inflammasome research has greatly contributed to our understanding of its role in inflammation and fibrosis development. The inflammasome is a multiprotein complex that is an important component of both the innate and adaptive immune systems. Activation of proinflammatory cytokines following inflammasome assembly, such as IL-1β and IL-18, has been associated with development of PF. In addition, components of the inflammasome complex itself, such as the adaptor protein ASC have been associated with PF development. Recent evidence suggesting that the fibrotic process can be reversed via blockade of pathways associated with inflammasome activity may provide hope for future drug strategies. In this paper we will give an introduction to pulmonary fibrosis and its known causes. In addition, we will discuss the importance of the inflammasome in the development of pulmonary fibrosis as well as discuss potential future treatment options. |
| format | Article |
| id | doaj-art-ca02b56e3bb14092bf6f7ed803506a5e |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-ca02b56e3bb14092bf6f7ed803506a5e2025-02-03T06:14:16ZengWileyPulmonary Medicine2090-18362090-18442011-01-01201110.1155/2011/105707105707Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary FibrosisRupa Biswas0Melisa Bunderson-Schelvan1Andrij Holian2Center for Environmental Health Sciences, The University of Montana, Skaggs Building 274, Missoula, MT 59812, USACenter for Environmental Health Sciences, The University of Montana, Skaggs Building 274, Missoula, MT 59812, USACenter for Environmental Health Sciences, The University of Montana, Skaggs Building 274, Missoula, MT 59812, USAPulmonary fibrosis is a progressive, disabling disease with mortality rates that appear to be increasing in the western population, including the USA. There are over 140 known causes of pulmonary fibrosis as well as many unknown causes. Treatment options for this disease are limited due to poor understanding of the molecular mechanisms of the disease progression. However, recent progress in inflammasome research has greatly contributed to our understanding of its role in inflammation and fibrosis development. The inflammasome is a multiprotein complex that is an important component of both the innate and adaptive immune systems. Activation of proinflammatory cytokines following inflammasome assembly, such as IL-1β and IL-18, has been associated with development of PF. In addition, components of the inflammasome complex itself, such as the adaptor protein ASC have been associated with PF development. Recent evidence suggesting that the fibrotic process can be reversed via blockade of pathways associated with inflammasome activity may provide hope for future drug strategies. In this paper we will give an introduction to pulmonary fibrosis and its known causes. In addition, we will discuss the importance of the inflammasome in the development of pulmonary fibrosis as well as discuss potential future treatment options.http://dx.doi.org/10.1155/2011/105707 |
| spellingShingle | Rupa Biswas Melisa Bunderson-Schelvan Andrij Holian Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis Pulmonary Medicine |
| title | Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis |
| title_full | Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis |
| title_fullStr | Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis |
| title_full_unstemmed | Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis |
| title_short | Potential Role of the Inflammasome-Derived Inflammatory Cytokines in Pulmonary Fibrosis |
| title_sort | potential role of the inflammasome derived inflammatory cytokines in pulmonary fibrosis |
| url | http://dx.doi.org/10.1155/2011/105707 |
| work_keys_str_mv | AT rupabiswas potentialroleoftheinflammasomederivedinflammatorycytokinesinpulmonaryfibrosis AT melisabundersonschelvan potentialroleoftheinflammasomederivedinflammatorycytokinesinpulmonaryfibrosis AT andrijholian potentialroleoftheinflammasomederivedinflammatorycytokinesinpulmonaryfibrosis |