Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy
Purpose. To evaluate the feasibility of wide-field Megahertz (MHz) OCT imaging in patients with diabetic retinopathy. Methods. A consecutive series of 15 eyes of 15 patients with diagnosed diabetic retinopathy were included. All patients underwent Megahertz OCT imaging, a close clinical examination,...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/305084 |
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| author | Lukas Reznicek Jan P. Kolb Thomas Klein Kathrin J. Mohler Wolfgang Wieser Robert Huber Marcus Kernt Josef Märtz Aljoscha S. Neubauer |
| author_facet | Lukas Reznicek Jan P. Kolb Thomas Klein Kathrin J. Mohler Wolfgang Wieser Robert Huber Marcus Kernt Josef Märtz Aljoscha S. Neubauer |
| author_sort | Lukas Reznicek |
| collection | DOAJ |
| description | Purpose. To evaluate the feasibility of wide-field Megahertz (MHz) OCT imaging in patients with diabetic retinopathy. Methods. A consecutive series of 15 eyes of 15 patients with diagnosed diabetic retinopathy were included. All patients underwent Megahertz OCT imaging, a close clinical examination, slit lamp biomicroscopy, and funduscopic evaluation. To acquire densely sampled, wide-field volumetric datasets, an ophthalmic 1050 nm OCT prototype system based on a Fourier-domain mode-locked (FDML) laser source with 1.68 MHz A-scan rate was employed. Results. We were able to obtain OCT volume scans from all included 15 patients. Acquisition time was 1.8 seconds. Obtained volume datasets consisted of 2088 × 1044 A-scans of 60° of view. Thus, reconstructed en face images had a resolution of 34.8 pixels per degree in x-axis and 17.4 pixels per degree. Due to the densely sampled OCT volume dataset, postprocessed customized cross-sectional B-frames through pathologic changes such as an individual microaneurysm or a retinal neovascularization could be imaged. Conclusions. Wide-field Megahertz OCT is feasible to successfully image patients with diabetic retinopathy at high scanning rates and a wide angle of view, providing information in all three axes. The Megahertz OCT is a useful tool to screen diabetic patients for diabetic retinopathy. |
| format | Article |
| id | doaj-art-c9ff7cd94d8845f698d1c841cf77650c |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c9ff7cd94d8845f698d1c841cf77650c2025-02-03T06:07:26ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/305084305084Wide-Field Megahertz OCT Imaging of Patients with Diabetic RetinopathyLukas Reznicek0Jan P. Kolb1Thomas Klein2Kathrin J. Mohler3Wolfgang Wieser4Robert Huber5Marcus Kernt6Josef Märtz7Aljoscha S. Neubauer8Department of Ophthalmology, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, GermanyInstitute for Biomolecular Optics, Ludwig Maximilians University, Oettingenstrasse 67, 80538 Munich, GermanyInstitute for Biomolecular Optics, Ludwig Maximilians University, Oettingenstrasse 67, 80538 Munich, GermanyInstitute for Biomolecular Optics, Ludwig Maximilians University, Oettingenstrasse 67, 80538 Munich, GermanyInstitute for Biomolecular Optics, Ludwig Maximilians University, Oettingenstrasse 67, 80538 Munich, GermanyInstitute of Biomedical Optics, University of Lübeck, Peter-Monnik-Weg 4, 23562 Lübeck, GermanyDepartment of Ophthalmology, Ludwig Maximilians University, Mathildenstrasse 8, 80336 Munich, GermanyDepartment of Ophthalmology, Ludwig Maximilians University, Mathildenstrasse 8, 80336 Munich, GermanyDepartment of Ophthalmology, Ludwig Maximilians University, Mathildenstrasse 8, 80336 Munich, GermanyPurpose. To evaluate the feasibility of wide-field Megahertz (MHz) OCT imaging in patients with diabetic retinopathy. Methods. A consecutive series of 15 eyes of 15 patients with diagnosed diabetic retinopathy were included. All patients underwent Megahertz OCT imaging, a close clinical examination, slit lamp biomicroscopy, and funduscopic evaluation. To acquire densely sampled, wide-field volumetric datasets, an ophthalmic 1050 nm OCT prototype system based on a Fourier-domain mode-locked (FDML) laser source with 1.68 MHz A-scan rate was employed. Results. We were able to obtain OCT volume scans from all included 15 patients. Acquisition time was 1.8 seconds. Obtained volume datasets consisted of 2088 × 1044 A-scans of 60° of view. Thus, reconstructed en face images had a resolution of 34.8 pixels per degree in x-axis and 17.4 pixels per degree. Due to the densely sampled OCT volume dataset, postprocessed customized cross-sectional B-frames through pathologic changes such as an individual microaneurysm or a retinal neovascularization could be imaged. Conclusions. Wide-field Megahertz OCT is feasible to successfully image patients with diabetic retinopathy at high scanning rates and a wide angle of view, providing information in all three axes. The Megahertz OCT is a useful tool to screen diabetic patients for diabetic retinopathy.http://dx.doi.org/10.1155/2015/305084 |
| spellingShingle | Lukas Reznicek Jan P. Kolb Thomas Klein Kathrin J. Mohler Wolfgang Wieser Robert Huber Marcus Kernt Josef Märtz Aljoscha S. Neubauer Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy Journal of Diabetes Research |
| title | Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy |
| title_full | Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy |
| title_fullStr | Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy |
| title_full_unstemmed | Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy |
| title_short | Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy |
| title_sort | wide field megahertz oct imaging of patients with diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2015/305084 |
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