Phosphate binder in dialysis: a cross-sectional study of patients' adherence and pill burden
Abstract Introduction: Phosphate (P) binders are among the most common medications prescribed to control P levels in patients with chronic kidney disease on dialysis. There is still a paucity of data on adherence to P binders with no comparison between dialysis modalities. Methods: We accessed fac...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Nefrologia
2025-01-01
|
| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000100307&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592468177059840 |
|---|---|
| author | Brunelle Bruna Scavello Coelho Ferezin Luiza Karla Ramos Pereira de Araújo Carolina Marquez Lima Hugo Abensur Benedito Jorge Pereira Maria Aparecida Dalboni Rosa Maria Affonso Moyses Rosilene Motta Elias |
| author_facet | Brunelle Bruna Scavello Coelho Ferezin Luiza Karla Ramos Pereira de Araújo Carolina Marquez Lima Hugo Abensur Benedito Jorge Pereira Maria Aparecida Dalboni Rosa Maria Affonso Moyses Rosilene Motta Elias |
| author_sort | Brunelle Bruna Scavello Coelho Ferezin |
| collection | DOAJ |
| description | Abstract Introduction: Phosphate (P) binders are among the most common medications prescribed to control P levels in patients with chronic kidney disease on dialysis. There is still a paucity of data on adherence to P binders with no comparison between dialysis modalities. Methods: We accessed factors associated with P binder adherence among patients on dialysis in an academic hospital. Adherence was calculated as the ratio between the number of pills taken per day as reported and the prescribed number of pills. Patients were considered non-adherent if adherence was at least 20% less or 30% more than prescribed. Results: Patients (N = 137) were young, mostly women, and on dialysis for a median time of 53 months. Sevelamer and calcium carbonate were prescribed as P binders to 70.8% and 10.2% of patients, respectively, with no difference across dialysis modalities (p = 0.839). P correlated with the number of pills prescribed (r = 0.368, p = 0.001) and the number of pills taken per day (r = 0.275, p = 0.001). Hyperphosphatemia was found in 52 patients (36.4%). Adherence to Ca carbonate and sevelamer was 100% and 68.4%, respectively. Non-adherent patients were women, younger, with higher serum albumin and urea, and lower serum calcium. Logistic regression showed that female sex (HR 3.30, 95% CI: 1.39–7.84, p = 0.007) and hemodialysis vs. peritoneal dialysis (HR 4.55, 95%, CI: 1.26–16.39, p = 0.021) remained independently associated with a non-adherence behavior. Conclusions: The current study suggests that strategies to increase adherence should be implemented. Whether phosphate binder adherence is associated with better outcomes deserves further investigation. |
| format | Article |
| id | doaj-art-c9ebaed8bddd4801942383fc6843eeca |
| institution | Kabale University |
| issn | 2175-8239 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj-art-c9ebaed8bddd4801942383fc6843eeca2025-01-21T07:43:37ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392025-01-0147110.1590/2175-8239-jbn-2024-0075enPhosphate binder in dialysis: a cross-sectional study of patients' adherence and pill burdenBrunelle Bruna Scavello Coelho Ferezinhttps://orcid.org/0009-0005-4553-537XLuiza Karla Ramos Pereira de Araújohttps://orcid.org/0000-0002-5529-5841Carolina Marquez Limahttps://orcid.org/0009-0006-5212-9836Hugo Abensurhttps://orcid.org/0000-0002-2102-4058Benedito Jorge Pereirahttps://orcid.org/0000-0002-7020-4573Maria Aparecida Dalbonihttps://orcid.org/0000-0002-9282-7181Rosa Maria Affonso Moyseshttps://orcid.org/0000-0002-7902-2127Rosilene Motta Eliashttps://orcid.org/0000-0003-2212-041XAbstract Introduction: Phosphate (P) binders are among the most common medications prescribed to control P levels in patients with chronic kidney disease on dialysis. There is still a paucity of data on adherence to P binders with no comparison between dialysis modalities. Methods: We accessed factors associated with P binder adherence among patients on dialysis in an academic hospital. Adherence was calculated as the ratio between the number of pills taken per day as reported and the prescribed number of pills. Patients were considered non-adherent if adherence was at least 20% less or 30% more than prescribed. Results: Patients (N = 137) were young, mostly women, and on dialysis for a median time of 53 months. Sevelamer and calcium carbonate were prescribed as P binders to 70.8% and 10.2% of patients, respectively, with no difference across dialysis modalities (p = 0.839). P correlated with the number of pills prescribed (r = 0.368, p = 0.001) and the number of pills taken per day (r = 0.275, p = 0.001). Hyperphosphatemia was found in 52 patients (36.4%). Adherence to Ca carbonate and sevelamer was 100% and 68.4%, respectively. Non-adherent patients were women, younger, with higher serum albumin and urea, and lower serum calcium. Logistic regression showed that female sex (HR 3.30, 95% CI: 1.39–7.84, p = 0.007) and hemodialysis vs. peritoneal dialysis (HR 4.55, 95%, CI: 1.26–16.39, p = 0.021) remained independently associated with a non-adherence behavior. Conclusions: The current study suggests that strategies to increase adherence should be implemented. Whether phosphate binder adherence is associated with better outcomes deserves further investigation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000100307&lng=en&tlng=enPhosphate BinderP BinderChronic Kidney DiseaseDialysisHyperphosphatemiaSevelamerCalcium Carbonate |
| spellingShingle | Brunelle Bruna Scavello Coelho Ferezin Luiza Karla Ramos Pereira de Araújo Carolina Marquez Lima Hugo Abensur Benedito Jorge Pereira Maria Aparecida Dalboni Rosa Maria Affonso Moyses Rosilene Motta Elias Phosphate binder in dialysis: a cross-sectional study of patients' adherence and pill burden Brazilian Journal of Nephrology Phosphate Binder P Binder Chronic Kidney Disease Dialysis Hyperphosphatemia Sevelamer Calcium Carbonate |
| title | Phosphate binder in dialysis: a cross-sectional study of patients' adherence and pill burden |
| title_full | Phosphate binder in dialysis: a cross-sectional study of patients' adherence and pill burden |
| title_fullStr | Phosphate binder in dialysis: a cross-sectional study of patients' adherence and pill burden |
| title_full_unstemmed | Phosphate binder in dialysis: a cross-sectional study of patients' adherence and pill burden |
| title_short | Phosphate binder in dialysis: a cross-sectional study of patients' adherence and pill burden |
| title_sort | phosphate binder in dialysis a cross sectional study of patients adherence and pill burden |
| topic | Phosphate Binder P Binder Chronic Kidney Disease Dialysis Hyperphosphatemia Sevelamer Calcium Carbonate |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000100307&lng=en&tlng=en |
| work_keys_str_mv | AT brunellebrunascavellocoelhoferezin phosphatebinderindialysisacrosssectionalstudyofpatientsadherenceandpillburden AT luizakarlaramospereiradearaujo phosphatebinderindialysisacrosssectionalstudyofpatientsadherenceandpillburden AT carolinamarquezlima phosphatebinderindialysisacrosssectionalstudyofpatientsadherenceandpillburden AT hugoabensur phosphatebinderindialysisacrosssectionalstudyofpatientsadherenceandpillburden AT beneditojorgepereira phosphatebinderindialysisacrosssectionalstudyofpatientsadherenceandpillburden AT mariaaparecidadalboni phosphatebinderindialysisacrosssectionalstudyofpatientsadherenceandpillburden AT rosamariaaffonsomoyses phosphatebinderindialysisacrosssectionalstudyofpatientsadherenceandpillburden AT rosilenemottaelias phosphatebinderindialysisacrosssectionalstudyofpatientsadherenceandpillburden |