Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease

Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease

Abstract Pompe disease is a metabolic myopathy due to acid alpha‐glucosidase deficiency. In addition to glycogen storage, secondary dysregulation of cellular functions, such as autophagy and oxidative stress, contributes to the disease pathophysiology. We have tested whether oxidative stress impacts...

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Main Authors: Antonietta Tarallo, Carla Damiano, Sandra Strollo, Nadia Minopoli, Alessia Indrieri, Elena Polishchuk, Francesca Zappa, Edoardo Nusco, Simona Fecarotta, Caterina Porto, Marcella Coletta, Roberta Iacono, Marco Moracci, Roman Polishchuk, Diego Luis Medina, Paola Imbimbo, Daria Maria Monti, Maria Antonietta De Matteis, Giancarlo Parenti
Format: Article
Language:English
Published: Springer Nature 2021-10-01
Series:EMBO Molecular Medicine
Subjects:
alpha‐glucosidase
enzyme replacement therapy
N‐acetylcysteine
oxidative stress
Pompe disease
Online Access:https://doi.org/10.15252/emmm.202114434
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