Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis
In the skin, the epidermis is continuously exposed to various kinds of external substances and stimuli. Therefore, epidermal barriers are crucial for providing protection, safeguarding health, and regulating water balance by maintaining skin homeostasis. Disruption of the epidermal barrier allows ex...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5404093 |
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| author | Youichi Ogawa Manao Kinoshita Shinji Shimada Tatsuyoshi Kawamura |
| author_facet | Youichi Ogawa Manao Kinoshita Shinji Shimada Tatsuyoshi Kawamura |
| author_sort | Youichi Ogawa |
| collection | DOAJ |
| description | In the skin, the epidermis is continuously exposed to various kinds of external substances and stimuli. Therefore, epidermal barriers are crucial for providing protection, safeguarding health, and regulating water balance by maintaining skin homeostasis. Disruption of the epidermal barrier allows external substances and stimuli to invade or stimulate the epidermal cells, leading to the elicitation of skin inflammation. The major components of the epidermal barrier are the stratum corneum (SC) and tight junctions (TJs). The presence of zinc in the epidermis promotes epidermal homeostasis; hence, this study reviewed the role of zinc in the formation and function of the SC and TJs. Langerhans cells (LCs) are one of the antigen-presenting cells found in the epidermis. They form TJs with adjacent keratinocytes (KCs), capture external antigens, and induce antigen-specific immune reactions. Thus, the function of zinc in LCs was examined in this review. We also summarized the general knowledge of zinc and zinc transporters in the epidermis with updated findings. |
| format | Article |
| id | doaj-art-c9cb16e000524336a4183756c394288c |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c9cb16e000524336a4183756c394288c2025-02-03T05:49:36ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/54040935404093Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal HomeostasisYouichi Ogawa0Manao Kinoshita1Shinji Shimada2Tatsuyoshi Kawamura3Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, JapanDepartment of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, JapanDepartment of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, JapanDepartment of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, JapanIn the skin, the epidermis is continuously exposed to various kinds of external substances and stimuli. Therefore, epidermal barriers are crucial for providing protection, safeguarding health, and regulating water balance by maintaining skin homeostasis. Disruption of the epidermal barrier allows external substances and stimuli to invade or stimulate the epidermal cells, leading to the elicitation of skin inflammation. The major components of the epidermal barrier are the stratum corneum (SC) and tight junctions (TJs). The presence of zinc in the epidermis promotes epidermal homeostasis; hence, this study reviewed the role of zinc in the formation and function of the SC and TJs. Langerhans cells (LCs) are one of the antigen-presenting cells found in the epidermis. They form TJs with adjacent keratinocytes (KCs), capture external antigens, and induce antigen-specific immune reactions. Thus, the function of zinc in LCs was examined in this review. We also summarized the general knowledge of zinc and zinc transporters in the epidermis with updated findings.http://dx.doi.org/10.1155/2018/5404093 |
| spellingShingle | Youichi Ogawa Manao Kinoshita Shinji Shimada Tatsuyoshi Kawamura Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis Journal of Immunology Research |
| title | Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis |
| title_full | Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis |
| title_fullStr | Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis |
| title_full_unstemmed | Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis |
| title_short | Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis |
| title_sort | zinc in keratinocytes and langerhans cells relevance to the epidermal homeostasis |
| url | http://dx.doi.org/10.1155/2018/5404093 |
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