Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals?
Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are retained in human skeletal muscle cells raised in culture. Together, these find...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/250496 |
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| author | Joseph A. Houmard Walter J. Pories G. Lynis Dohm |
| author_facet | Joseph A. Houmard Walter J. Pories G. Lynis Dohm |
| author_sort | Joseph A. Houmard |
| collection | DOAJ |
| description | Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are retained in human skeletal muscle cells raised in culture. Together, these findings are indicative of a dysfunctional global metabolic program with severe obesity which is of an epigenetic or genetic origin. Weight loss via gastric bypass surgery can “turn off” and/or correct components of this metabolic program as insulin sensitivity is restored; however, the impairment in FAO in skeletal muscle remains evident. Physical activity can improve FAO and insulin action, indicating that this patient population is not exercise resistant and that exercise offers a pathway to circumvent the abnormal program. Findings presented in this review will hopefully increase the understanding of and aid in preventing and/or treating the severely obese condition. |
| format | Article |
| id | doaj-art-c9c561781a884b0ebca595336842855e |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-c9c561781a884b0ebca595336842855e2025-02-03T06:01:30ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/250496250496Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals?Joseph A. Houmard0Walter J. Pories1G. Lynis Dohm2Department of Exercise and Sport Science, College of Health and Human Performance, East Carolina University, Greenville, NC 27834, USAEast Carolina Diabetes and Obesity Center, East Carolina University, Greenville, NC 27858, USAEast Carolina Diabetes and Obesity Center, East Carolina University, Greenville, NC 27858, USASevere obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are retained in human skeletal muscle cells raised in culture. Together, these findings are indicative of a dysfunctional global metabolic program with severe obesity which is of an epigenetic or genetic origin. Weight loss via gastric bypass surgery can “turn off” and/or correct components of this metabolic program as insulin sensitivity is restored; however, the impairment in FAO in skeletal muscle remains evident. Physical activity can improve FAO and insulin action, indicating that this patient population is not exercise resistant and that exercise offers a pathway to circumvent the abnormal program. Findings presented in this review will hopefully increase the understanding of and aid in preventing and/or treating the severely obese condition.http://dx.doi.org/10.1155/2011/250496 |
| spellingShingle | Joseph A. Houmard Walter J. Pories G. Lynis Dohm Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals? Journal of Obesity |
| title | Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals? |
| title_full | Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals? |
| title_fullStr | Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals? |
| title_full_unstemmed | Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals? |
| title_short | Is There a Metabolic Program in the Skeletal Muscle of Obese Individuals? |
| title_sort | is there a metabolic program in the skeletal muscle of obese individuals |
| url | http://dx.doi.org/10.1155/2011/250496 |
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