Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic Period
Background. Patients after polytrauma regularly suffer from posttraumatic immune system destabilization, which closely influences the further clinical development. Increasing age has recently been identified as an isolated risk factor for an adverse outcome after major trauma. Higher rates and inten...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/4936374 |
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| author | Mareen Braunstein Thomas Kusmenkov Wolf Mutschler Christian Kammerlander Wolfgang Böcker Viktoria Bogner-Flatz |
| author_facet | Mareen Braunstein Thomas Kusmenkov Wolf Mutschler Christian Kammerlander Wolfgang Böcker Viktoria Bogner-Flatz |
| author_sort | Mareen Braunstein |
| collection | DOAJ |
| description | Background. Patients after polytrauma regularly suffer from posttraumatic immune system destabilization, which closely influences the further clinical development. Increasing age has recently been identified as an isolated risk factor for an adverse outcome after major trauma. Higher rates and intensity of acute inflammation following severe injury suggest that deregulated inflammation may contribute to these higher rates of posttraumatic morbidity and mortality in older adults. MMP-9 and TIMP-1 have been found to play a major role in posttraumatic immune disorder in a previous genome-wide mRNA analysis. Objective. The aim of this study was to evaluate the differences in serum protein dynamics in older and younger polytraumatized adults. Methods. Blood samples were drawn immediately within 90 minutes after trauma and subsequently after 6, 12, 24, 48, and 72 h. Serum levels of TIMP-1 and MMP-9 were quantified using ELISA. Age groups were divided according to a cutoff of 60 years. Results. 60 polytrauma patients (ISS>16) were included (<60 years, n=49; ≥60 years, n=11). Serum TIMP-1 and MMP-9 levels showed a highly significant serum dynamic in young and old polytrauma patients (p<0.001). Patients≥60 years showed significantly higher overall TIMP-1 levels (p=0.008). TIMP-1 levels showed a significant maximum after 72 h in the older study population. MMP-9 levels were nonsignificantly higher during the whole observational period in older polytrauma patients when compared to younger patients. Conclusion. The posttraumatic immune response is characterized by significantly higher TIMP-1 levels in older polytrauma patients. This significant association between TIMP-1 levels and patients’ age indicates a more extensive immune dysregulation following major trauma in older adults. |
| format | Article |
| id | doaj-art-c9baca97ed5640aa9985e4650b1307e5 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c9baca97ed5640aa9985e4650b1307e52025-02-03T01:04:37ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/49363744936374Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic PeriodMareen Braunstein0Thomas Kusmenkov1Wolf Mutschler2Christian Kammerlander3Wolfgang Böcker4Viktoria Bogner-Flatz5Department of Trauma Surgery, University Hospital Munich, Ludwig-Maximilians University, Nussbaumstr. 20, 80336 Munich, GermanyDepartment of Trauma Surgery, University Hospital Munich, Ludwig-Maximilians University, Nussbaumstr. 20, 80336 Munich, GermanyDepartment of Trauma Surgery, University Hospital Munich, Ludwig-Maximilians University, Nussbaumstr. 20, 80336 Munich, GermanyDepartment of Trauma Surgery, University Hospital Munich, Ludwig-Maximilians University, Nussbaumstr. 20, 80336 Munich, GermanyDepartment of Trauma Surgery, University Hospital Munich, Ludwig-Maximilians University, Nussbaumstr. 20, 80336 Munich, GermanyDepartment of Trauma Surgery, University Hospital Munich, Ludwig-Maximilians University, Nussbaumstr. 20, 80336 Munich, GermanyBackground. Patients after polytrauma regularly suffer from posttraumatic immune system destabilization, which closely influences the further clinical development. Increasing age has recently been identified as an isolated risk factor for an adverse outcome after major trauma. Higher rates and intensity of acute inflammation following severe injury suggest that deregulated inflammation may contribute to these higher rates of posttraumatic morbidity and mortality in older adults. MMP-9 and TIMP-1 have been found to play a major role in posttraumatic immune disorder in a previous genome-wide mRNA analysis. Objective. The aim of this study was to evaluate the differences in serum protein dynamics in older and younger polytraumatized adults. Methods. Blood samples were drawn immediately within 90 minutes after trauma and subsequently after 6, 12, 24, 48, and 72 h. Serum levels of TIMP-1 and MMP-9 were quantified using ELISA. Age groups were divided according to a cutoff of 60 years. Results. 60 polytrauma patients (ISS>16) were included (<60 years, n=49; ≥60 years, n=11). Serum TIMP-1 and MMP-9 levels showed a highly significant serum dynamic in young and old polytrauma patients (p<0.001). Patients≥60 years showed significantly higher overall TIMP-1 levels (p=0.008). TIMP-1 levels showed a significant maximum after 72 h in the older study population. MMP-9 levels were nonsignificantly higher during the whole observational period in older polytrauma patients when compared to younger patients. Conclusion. The posttraumatic immune response is characterized by significantly higher TIMP-1 levels in older polytrauma patients. This significant association between TIMP-1 levels and patients’ age indicates a more extensive immune dysregulation following major trauma in older adults.http://dx.doi.org/10.1155/2020/4936374 |
| spellingShingle | Mareen Braunstein Thomas Kusmenkov Wolf Mutschler Christian Kammerlander Wolfgang Böcker Viktoria Bogner-Flatz Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic Period Journal of Immunology Research |
| title | Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic Period |
| title_full | Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic Period |
| title_fullStr | Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic Period |
| title_full_unstemmed | Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic Period |
| title_short | Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic Period |
| title_sort | polytrauma in older adults leads to significantly increased timp 1 levels in the early posttraumatic period |
| url | http://dx.doi.org/10.1155/2020/4936374 |
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