Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus
Insufficient sleep can produce a multitude of deleterious repercussions on various domains of human well-being. Concomitantly, the walnut (Juglans mandshurica) confers numerous salutary biological activities pertaining to sleep. Nevertheless, the sedative and hypnotic capacities of walnut’s function...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2023-01-01
|
| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0216 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586959303737344 |
|---|---|
| author | Jian Ji Yongli Ye Lina Sheng Jiadi Sun Qianqian Hong Chang Liu Jun Ding Shuxiang Geng Deping Xu Yinzhi Zhang Xiulan Sun |
| author_facet | Jian Ji Yongli Ye Lina Sheng Jiadi Sun Qianqian Hong Chang Liu Jun Ding Shuxiang Geng Deping Xu Yinzhi Zhang Xiulan Sun |
| author_sort | Jian Ji |
| collection | DOAJ |
| description | Insufficient sleep can produce a multitude of deleterious repercussions on various domains of human well-being. Concomitantly, the walnut (Juglans mandshurica) confers numerous salutary biological activities pertaining to sleep. Nevertheless, the sedative and hypnotic capacities of walnut’s functional constituents remain obscure. In this investigation, we analyzed the sedative and hypnotic components of the walnut Diaphragma juglandis fructus and innovatively discovered a compound, defined as 3-hydroxy-4-iminobutyric acid (HIBA), which disrupts motor activity and enhances sleep duration by regulating the neurotransmitters (GABA, DA, etc.) within the brain and serum of mice. Subsequently, a metabolomics approach of the serum, basal ganglia, hypothalamus, and hippocampus as well as the gut microbiota was undertaken to unravel the underlying molecular mechanisms of sleep promotion. Our data reveal that HIBA can regulate the metabolism of basal ganglia (sphingolipids, acylcarnitines, etc.), possibly in relation to HIBA’s influence on the gut microbiome (Muribaculum, Bacteroides, Lactobacillus, etc.). Therefore, we introduce a novel natural product, HIBA, and explicate the modulation of sleep promotion in mice based on the microbiota–gut–brain axis. This study contributes fresh insights toward natural product-based sleep research. |
| format | Article |
| id | doaj-art-c9b46e0aa67c44d0a005a4779bf7cdae |
| institution | Kabale University |
| issn | 2639-5274 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj-art-c9b46e0aa67c44d0a005a4779bf7cdae2025-01-24T20:12:32ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742023-01-01610.34133/research.0216Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis FructusJian Ji0Yongli Ye1Lina Sheng2Jiadi Sun3Qianqian Hong4Chang Liu5Jun Ding6Shuxiang Geng7Deping Xu8Yinzhi Zhang9Xiulan Sun10State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Avenue 1800, Wuxi, Jiangsu 214100, P.R. China.State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Avenue 1800, Wuxi, Jiangsu 214100, P.R. China.State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Avenue 1800, Wuxi, Jiangsu 214100, P.R. China.State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Avenue 1800, Wuxi, Jiangsu 214100, P.R. China.State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Avenue 1800, Wuxi, Jiangsu 214100, P.R. China.State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Avenue 1800, Wuxi, Jiangsu 214100, P.R. China.Department of Chemistry, Wuhan University, Wuhan, Hubei 430072, P.R. China.Yunnan Academy of Forestry and Grassland, Kunming, Yunnan 650201, P.R. China.State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Avenue 1800, Wuxi, Jiangsu 214100, P.R. China.State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Avenue 1800, Wuxi, Jiangsu 214100, P.R. China.State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Avenue 1800, Wuxi, Jiangsu 214100, P.R. China.Insufficient sleep can produce a multitude of deleterious repercussions on various domains of human well-being. Concomitantly, the walnut (Juglans mandshurica) confers numerous salutary biological activities pertaining to sleep. Nevertheless, the sedative and hypnotic capacities of walnut’s functional constituents remain obscure. In this investigation, we analyzed the sedative and hypnotic components of the walnut Diaphragma juglandis fructus and innovatively discovered a compound, defined as 3-hydroxy-4-iminobutyric acid (HIBA), which disrupts motor activity and enhances sleep duration by regulating the neurotransmitters (GABA, DA, etc.) within the brain and serum of mice. Subsequently, a metabolomics approach of the serum, basal ganglia, hypothalamus, and hippocampus as well as the gut microbiota was undertaken to unravel the underlying molecular mechanisms of sleep promotion. Our data reveal that HIBA can regulate the metabolism of basal ganglia (sphingolipids, acylcarnitines, etc.), possibly in relation to HIBA’s influence on the gut microbiome (Muribaculum, Bacteroides, Lactobacillus, etc.). Therefore, we introduce a novel natural product, HIBA, and explicate the modulation of sleep promotion in mice based on the microbiota–gut–brain axis. This study contributes fresh insights toward natural product-based sleep research.https://spj.science.org/doi/10.34133/research.0216 |
| spellingShingle | Jian Ji Yongli Ye Lina Sheng Jiadi Sun Qianqian Hong Chang Liu Jun Ding Shuxiang Geng Deping Xu Yinzhi Zhang Xiulan Sun Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus Research |
| title | Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus |
| title_full | Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus |
| title_fullStr | Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus |
| title_full_unstemmed | Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus |
| title_short | Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus |
| title_sort | sleep promotion by 3 hydroxy 4 iminobutyric acid in walnut diaphragma juglandis fructus |
| url | https://spj.science.org/doi/10.34133/research.0216 |
| work_keys_str_mv | AT jianji sleeppromotionby3hydroxy4iminobutyricacidinwalnutdiaphragmajuglandisfructus AT yongliye sleeppromotionby3hydroxy4iminobutyricacidinwalnutdiaphragmajuglandisfructus AT linasheng sleeppromotionby3hydroxy4iminobutyricacidinwalnutdiaphragmajuglandisfructus AT jiadisun sleeppromotionby3hydroxy4iminobutyricacidinwalnutdiaphragmajuglandisfructus AT qianqianhong sleeppromotionby3hydroxy4iminobutyricacidinwalnutdiaphragmajuglandisfructus AT changliu sleeppromotionby3hydroxy4iminobutyricacidinwalnutdiaphragmajuglandisfructus AT junding sleeppromotionby3hydroxy4iminobutyricacidinwalnutdiaphragmajuglandisfructus AT shuxianggeng sleeppromotionby3hydroxy4iminobutyricacidinwalnutdiaphragmajuglandisfructus AT depingxu sleeppromotionby3hydroxy4iminobutyricacidinwalnutdiaphragmajuglandisfructus AT yinzhizhang sleeppromotionby3hydroxy4iminobutyricacidinwalnutdiaphragmajuglandisfructus AT xiulansun sleeppromotionby3hydroxy4iminobutyricacidinwalnutdiaphragmajuglandisfructus |