Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence
Objective evaluation of language function is critical for children with intractable epilepsy under consideration for epilepsy surgery. The purpose of this preliminary study was to evaluate word recognition in children with intractable epilepsy by using magnetoencephalography (MEG). Ten children with...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2015/237436 |
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| _version_ | 1832555156779040768 |
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| author | Maria Pardos Milena Korostenskaja Jing Xiang Hisako Fujiwara Ki H. Lee Paul S. Horn Anna Byars Jennifer Vannest Yingying Wang Nat Hemasilpin Douglas F. Rose |
| author_facet | Maria Pardos Milena Korostenskaja Jing Xiang Hisako Fujiwara Ki H. Lee Paul S. Horn Anna Byars Jennifer Vannest Yingying Wang Nat Hemasilpin Douglas F. Rose |
| author_sort | Maria Pardos |
| collection | DOAJ |
| description | Objective evaluation of language function is critical for children with intractable epilepsy under consideration for epilepsy surgery. The purpose of this preliminary study was to evaluate word recognition in children with intractable epilepsy by using magnetoencephalography (MEG). Ten children with intractable epilepsy (M/F 6/4, mean ± SD 13.4 ± 2.2 years) were matched on age and sex to healthy controls. Common nouns were presented simultaneously from visual and auditory sensory inputs in “match” and “mismatch” conditions. Neuromagnetic responses M1, M2, M3, M4, and M5 with latencies of ~100 ms, ~150 ms, ~250 ms, ~350 ms, and ~450 ms, respectively, elicited during the “match” condition were identified. Compared to healthy children, epilepsy patients had both significantly delayed latency of the M1 and reduced amplitudes of M3 and M5 responses. These results provide neurophysiologic evidence of altered word recognition in children with intractable epilepsy. |
| format | Article |
| id | doaj-art-c9b42e4ea4ea486bac406b523d102e5c |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-c9b42e4ea4ea486bac406b523d102e5c2025-02-03T05:49:28ZengWileyBehavioural Neurology0953-41801875-85842015-01-01201510.1155/2015/237436237436Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic EvidenceMaria Pardos0Milena Korostenskaja1Jing Xiang2Hisako Fujiwara3Ki H. Lee4Paul S. Horn5Anna Byars6Jennifer Vannest7Yingying Wang8Nat Hemasilpin9Douglas F. Rose10Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USAObjective evaluation of language function is critical for children with intractable epilepsy under consideration for epilepsy surgery. The purpose of this preliminary study was to evaluate word recognition in children with intractable epilepsy by using magnetoencephalography (MEG). Ten children with intractable epilepsy (M/F 6/4, mean ± SD 13.4 ± 2.2 years) were matched on age and sex to healthy controls. Common nouns were presented simultaneously from visual and auditory sensory inputs in “match” and “mismatch” conditions. Neuromagnetic responses M1, M2, M3, M4, and M5 with latencies of ~100 ms, ~150 ms, ~250 ms, ~350 ms, and ~450 ms, respectively, elicited during the “match” condition were identified. Compared to healthy children, epilepsy patients had both significantly delayed latency of the M1 and reduced amplitudes of M3 and M5 responses. These results provide neurophysiologic evidence of altered word recognition in children with intractable epilepsy.http://dx.doi.org/10.1155/2015/237436 |
| spellingShingle | Maria Pardos Milena Korostenskaja Jing Xiang Hisako Fujiwara Ki H. Lee Paul S. Horn Anna Byars Jennifer Vannest Yingying Wang Nat Hemasilpin Douglas F. Rose Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence Behavioural Neurology |
| title | Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence |
| title_full | Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence |
| title_fullStr | Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence |
| title_full_unstemmed | Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence |
| title_short | Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence |
| title_sort | physical feature encoding and word recognition abilities are altered in children with intractable epilepsy preliminary neuromagnetic evidence |
| url | http://dx.doi.org/10.1155/2015/237436 |
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