Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues
Abstract Visualizing mechanical stress distribution in soft and live biomaterials is essential for understanding biological processes and improving material design. However, it remains challenging due to their complexity, dynamic nature, and sensitivity requirements, necessitating innovative techniq...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56422-8 |
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| author | Fenghou Yuan Huitang Qi Binghui Song Yuntian Cui Junsheng Zhang Huan Liu Bo Liu Hai Lei Tian Liu |
| author_facet | Fenghou Yuan Huitang Qi Binghui Song Yuntian Cui Junsheng Zhang Huan Liu Bo Liu Hai Lei Tian Liu |
| author_sort | Fenghou Yuan |
| collection | DOAJ |
| description | Abstract Visualizing mechanical stress distribution in soft and live biomaterials is essential for understanding biological processes and improving material design. However, it remains challenging due to their complexity, dynamic nature, and sensitivity requirements, necessitating innovative techniques. Since polysaccharides are common in various biomaterials, a biosensor integrating a Förster resonance energy transfer (FRET)-based tension sensor module and carbohydrate-binding modules (FTSM-CBM) has been designed for real-time monitoring of the stress distribution of these biomaterials. By simple dripping or soaking, FTSM-CBM enables fast, reproducible and semiquantitative detection of both 2D and 3D stress distributions in polysaccharide-based hydrogels. Additionally, it provides valuable information such as microstructure hints and fracture site warnings. FTSM-CBM can also monitor the locomotion of maggots, which is not feasible with most existing techniques. Furthermore, by changing the CBM, FTSM-CBM can be expanded for various polysaccharide-based biomaterials. This study provides a powerful tool that may promote related research in life and materials science. |
| format | Article |
| id | doaj-art-c9af3c025890458598b272cc7eff1bfd |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-c9af3c025890458598b272cc7eff1bfd2025-02-02T12:31:22ZengNature PortfolioNature Communications2041-17232025-01-0116111010.1038/s41467-025-56422-8Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissuesFenghou Yuan0Huitang Qi1Binghui Song2Yuntian Cui3Junsheng Zhang4Huan Liu5Bo Liu6Hai Lei7Tian Liu8MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of TechnologyMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of TechnologyMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of TechnologyMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of TechnologySchool of Chemistry and Chemical Engineering, Ningxia UniversityMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of TechnologySchool of Biomedical Engineering, Liaoning Key Lab of Integrated Circuit and Bio-medical Electronic System, Dalian University of TechnologySchool of Physics, Institute for Advanced Study in Physics, Zhejiang UniversityMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of TechnologyAbstract Visualizing mechanical stress distribution in soft and live biomaterials is essential for understanding biological processes and improving material design. However, it remains challenging due to their complexity, dynamic nature, and sensitivity requirements, necessitating innovative techniques. Since polysaccharides are common in various biomaterials, a biosensor integrating a Förster resonance energy transfer (FRET)-based tension sensor module and carbohydrate-binding modules (FTSM-CBM) has been designed for real-time monitoring of the stress distribution of these biomaterials. By simple dripping or soaking, FTSM-CBM enables fast, reproducible and semiquantitative detection of both 2D and 3D stress distributions in polysaccharide-based hydrogels. Additionally, it provides valuable information such as microstructure hints and fracture site warnings. FTSM-CBM can also monitor the locomotion of maggots, which is not feasible with most existing techniques. Furthermore, by changing the CBM, FTSM-CBM can be expanded for various polysaccharide-based biomaterials. This study provides a powerful tool that may promote related research in life and materials science.https://doi.org/10.1038/s41467-025-56422-8 |
| spellingShingle | Fenghou Yuan Huitang Qi Binghui Song Yuntian Cui Junsheng Zhang Huan Liu Bo Liu Hai Lei Tian Liu Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues Nature Communications |
| title | Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues |
| title_full | Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues |
| title_fullStr | Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues |
| title_full_unstemmed | Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues |
| title_short | Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues |
| title_sort | tailorable biosensors for real time monitoring of stress distribution in soft biomaterials and living tissues |
| url | https://doi.org/10.1038/s41467-025-56422-8 |
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