Coactivation of Tie2 and Wnt signaling using an antibody–R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia

Coactivation of Tie2 and Wnt signaling using an antibody–R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia

Therapeutic angiogenesis by intentional formation of blood vessels is essential for treating various ischemic diseases, including limb ischemia. Because Wnt/β-catenin and angiopoietin-1/Tie2 signaling play important roles in endothelial survival and vascular stability, coactivation of these signalin...

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Main Authors: Byungtae Hwang, Min-Young Jeon, Ju-Hong Jang, Young-Lai Cho, Dong Gwang Lee, Jeong-Ki Min, Jangwook Lee, Jong-Gil Park, Ji-Hun Noh, Wonjun Yang, Nam-Kyung Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Bifunctional antibody
hindlimb ischemia
R-spondin
therapeutic angiogenesis
Tie2
vessel stabilization
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2435478
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https://www.tandfonline.com/doi/10.1080/19420862.2024.2435478

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