Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas aeruginosa Using Multiple Combination Bactericidal Testing
Early infection is a recognised complication after lung transplantation in patients with cystic fibrosis (CF). Our centre uses multiple combination bactericidal testing (MCBT) when determining appropriate peritransplant prophylactic regimens. To evaluate our strategy, we compared the incidence of po...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/135738 |
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| author | Helmy Haja Mydin Paul A. Corris Audrey Nicholson John D. Perry Gerard Meachery Emma C. L. Marrs Steven Peart Christine Fagan James L. Lordan Andrew J. Fisher Frances K. Gould |
| author_facet | Helmy Haja Mydin Paul A. Corris Audrey Nicholson John D. Perry Gerard Meachery Emma C. L. Marrs Steven Peart Christine Fagan James L. Lordan Andrew J. Fisher Frances K. Gould |
| author_sort | Helmy Haja Mydin |
| collection | DOAJ |
| description | Early infection is a recognised complication after lung transplantation in patients with cystic fibrosis (CF). Our centre uses multiple combination bactericidal testing (MCBT) when determining appropriate peritransplant prophylactic regimens. To evaluate our strategy, we compared the incidence of posttransplant infection in patients whose peritransplant antimicrobial regimens were determined using MCBT versus standard sensitivity testing.
Patients with CF who were infected with Pseudomonas aeruginosa and underwent lung transplantations between 2000 and 2010 were included. Data was collected from clinical records and our microbiology database. Microorganisms cultured were mapped against antibiotic resistance, method of sensitivity testing, and antibiotics administered peritransplant.
129 patients were identified (mean age 28, male : female, 63 : 66). Fifty patients (38.8%) had antibiotics determined by MCBT. Two patients in the MCBT group developed septicaemia, 13 in the conventional group (P≤0.05, 2-tailed Fisher's test). Sepsis was attributable to P. aeruginosa in one patient from the MCBT group and seven patients in the conventional group (P=0.15). P. aeruginosa was recovered from the posttransplant pleural fluid of one patient who received MCBT-guided prophylaxis, six patients in the conventional group (P=0.25). Patients given antibiotics based on MCBT had significantly lower rates of septicaemia and lower rates of empyema. |
| format | Article |
| id | doaj-art-c99bc6dba9c84d3689f05d8792cfa9e8 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-c99bc6dba9c84d3689f05d8792cfa9e82025-02-03T01:24:55ZengWileyJournal of Transplantation2090-00072090-00152012-01-01201210.1155/2012/135738135738Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas aeruginosa Using Multiple Combination Bactericidal TestingHelmy Haja Mydin0Paul A. Corris1Audrey Nicholson2John D. Perry3Gerard Meachery4Emma C. L. Marrs5Steven Peart6Christine Fagan7James L. Lordan8Andrew J. Fisher9Frances K. Gould10Institute of Transplantation, The Freeman Hospital, Newcastle upon Tyne NHS Hospitals Trust, High Heaton, Newcastle upon Tyne NE7 7DN, UKInstitute of Transplantation, The Freeman Hospital, Newcastle upon Tyne NHS Hospitals Trust, High Heaton, Newcastle upon Tyne NE7 7DN, UKDepartment of Medical Microbiology, The Freeman Hospital, Newcastle upon Tyne NHS Hospitals Trust, High Heaton, Newcastle upon Tyne NE7 7DN, UKDepartment of Medical Microbiology, The Freeman Hospital, Newcastle upon Tyne NHS Hospitals Trust, High Heaton, Newcastle upon Tyne NE7 7DN, UKInstitute of Transplantation, The Freeman Hospital, Newcastle upon Tyne NHS Hospitals Trust, High Heaton, Newcastle upon Tyne NE7 7DN, UKDepartment of Medical Microbiology, The Freeman Hospital, Newcastle upon Tyne NHS Hospitals Trust, High Heaton, Newcastle upon Tyne NE7 7DN, UKDepartment of Medical Microbiology, The Freeman Hospital, Newcastle upon Tyne NHS Hospitals Trust, High Heaton, Newcastle upon Tyne NE7 7DN, UKDepartment of Medical Microbiology, The Freeman Hospital, Newcastle upon Tyne NHS Hospitals Trust, High Heaton, Newcastle upon Tyne NE7 7DN, UKInstitute of Transplantation, The Freeman Hospital, Newcastle upon Tyne NHS Hospitals Trust, High Heaton, Newcastle upon Tyne NE7 7DN, UKInstitute of Transplantation, The Freeman Hospital, Newcastle upon Tyne NHS Hospitals Trust, High Heaton, Newcastle upon Tyne NE7 7DN, UKDepartment of Medical Microbiology, The Freeman Hospital, Newcastle upon Tyne NHS Hospitals Trust, High Heaton, Newcastle upon Tyne NE7 7DN, UKEarly infection is a recognised complication after lung transplantation in patients with cystic fibrosis (CF). Our centre uses multiple combination bactericidal testing (MCBT) when determining appropriate peritransplant prophylactic regimens. To evaluate our strategy, we compared the incidence of posttransplant infection in patients whose peritransplant antimicrobial regimens were determined using MCBT versus standard sensitivity testing. Patients with CF who were infected with Pseudomonas aeruginosa and underwent lung transplantations between 2000 and 2010 were included. Data was collected from clinical records and our microbiology database. Microorganisms cultured were mapped against antibiotic resistance, method of sensitivity testing, and antibiotics administered peritransplant. 129 patients were identified (mean age 28, male : female, 63 : 66). Fifty patients (38.8%) had antibiotics determined by MCBT. Two patients in the MCBT group developed septicaemia, 13 in the conventional group (P≤0.05, 2-tailed Fisher's test). Sepsis was attributable to P. aeruginosa in one patient from the MCBT group and seven patients in the conventional group (P=0.15). P. aeruginosa was recovered from the posttransplant pleural fluid of one patient who received MCBT-guided prophylaxis, six patients in the conventional group (P=0.25). Patients given antibiotics based on MCBT had significantly lower rates of septicaemia and lower rates of empyema.http://dx.doi.org/10.1155/2012/135738 |
| spellingShingle | Helmy Haja Mydin Paul A. Corris Audrey Nicholson John D. Perry Gerard Meachery Emma C. L. Marrs Steven Peart Christine Fagan James L. Lordan Andrew J. Fisher Frances K. Gould Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas aeruginosa Using Multiple Combination Bactericidal Testing Journal of Transplantation |
| title | Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas aeruginosa Using Multiple Combination Bactericidal Testing |
| title_full | Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas aeruginosa Using Multiple Combination Bactericidal Testing |
| title_fullStr | Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas aeruginosa Using Multiple Combination Bactericidal Testing |
| title_full_unstemmed | Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas aeruginosa Using Multiple Combination Bactericidal Testing |
| title_short | Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas aeruginosa Using Multiple Combination Bactericidal Testing |
| title_sort | targeted antibiotic prophylaxis for lung transplantation in cystic fibrosis patients colonised with pseudomonas aeruginosa using multiple combination bactericidal testing |
| url | http://dx.doi.org/10.1155/2012/135738 |
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